FB2024_03 , released June 25, 2024
Allele: Dmel\Ptp69D2
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General Information
Symbol
Dmel\Ptp69D2
Species
D. melanogaster
Name
FlyBase ID
FBal0048915
Feature type
allele
Associated gene
Dmel\Ptp69D
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Desai et al., 1996)
Progenitor genotype
Ptp69D11f3
(Desai et al., 1996)
Cytology
Description

Deletion removing N-terminal coding sequences, including the signal sequence and part of the first immunoglobulin domain. This enhanced phenotype is completely rescued by one copy of Ptp69D+t10.5.

(Desai et al., 1996)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows incompletely penetrant SNb (and, to a lesser extent, SNa) pathfinding defects. RP axons sometimes exhibit guidance errors within the CNS.

      (Desai et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Ptp69D2 has larval abdominal segmental nerve phenotype, enhanceable by Ptp99A1

      (Desai et al., 1996)

      Ptp69D2 has RP neuron & axon phenotype, enhanceable by Ptp99A1

      (Desai et al., 1996)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Penetrance and severity of mutant phenotypes is enhanced by Ptp99A1. The severity of the RP axon phenotype is enhanced by Ptp99A1.

      (Desai et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Rank order for penetrance of SNb mutant phenotypes is Ptp69D1 > Ptp69D2 > Ptp69D1/Ptp69D3 > Ptp69D3.

      (Desai et al., 1996)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Ptp69D2
      Name Synonyms
      Secondary FlyBase IDs
        References (1)