Deletion removing N-terminal coding sequences, including the signal sequence, the immunoglobulin domain and at least two of the fibronectin repeats.
Shows incompletely penetrant SNb (and, to a lesser extent, SNa) pathfinding defects. RP axons sometimes exhibit guidance errors within the CNS.
Ptp69D3 has larval abdominal segmental nerve phenotype, enhanceable by Ptp99A1
Penetrance and severity of mutant phenotypes is enhanced by Ptp99A1. This enhanced phenotype is completely rescued by one copy of Ptp69D+t10.5. The severity of the RP axon phenotype is enhanced by Ptp99A1.
Rank order for penetrance of SNb mutant phenotypes is Ptp69D1 > Ptp69D2 > Ptp69D1/Ptp69D3 > Ptp69D3.