Associated with a chromosomal rearrangement that causes a frameshift or truncation within the first 82 amino acids.
Embryos have little or no cuticle (epidermally derived structures are also abnormal), embryos fail to hatch into larvae. Trachea do not appear to be disrupted but they fail to fill with air in later embryos, possibly because they collapse due to insufficient cuticle deposition. Defects in the extracellular accumulation of secreted products was observed in other tissues: Malpighian tubules do not contain uric acid, the lumen of salivary glands contains severely reduced glue protein levels and the gut contents are incompletely digested due to lack of digestive enzymes. Morphology of the CNS is altered, fails to dissociate from the ventral epidermis and fails to shorten in mature embryos.
RopA3, btszK13-4 has tracheal lumen | embryonic stage phenotype
RopA3, btszK13-4 has embryonic/larval tracheal system | embryonic stage phenotype