FB2024_03 , released June 25, 2024
Allele: Dmel\btszK13-4
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General Information
Symbol
Dmel\btszK13-4
Species
D. melanogaster
Name
FlyBase ID
FBal0175740
Feature type
allele
Associated gene
Dmel\btsz
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Serano and Rubin, 2003)
Progenitor genotype
btsz10418
(Serano and Rubin, 2003)
Cytology
Description

Introduces a deletion in the amino terminus of the btsz2 isoform (residues 501-1494).

(Pilot et al., 2006)

Imprecise excision of P{PZ}btsz10418 has removed sequence encoding 991 aa of btsz isoform 2 protein, but does not alter the reading frame. Isoform 2 = GenBank:AY229970 ; exons 8 + 10-15.

(Serano and Rubin, 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      btszK13-4 embryos that manage to cellularize and complete gastrulation show a somewhat disrupted epidermis. The shapes of the apical circumferences of invaginating salivary gland placode cells are irregular. At stage 14, the epidermis in the region where the placodal cells were located previously is disrupted and lost.

      (Maybeck and Röper, 2009)

      Approximately 26% of btszK13-4 homozygous embryos reach cellularisation and exhibit epithelial defects during gastrulation. Approximately 46% of btszK13-4/btszJ5-2 embryos exhibit epithelial defects during gastrulation.

      Approximately 12% of btszK13-4/Df(3R)Exel6275 trans-heterozygous embryos show epithelial defects. Heterozygous btszK13-4/+ mutant males exhibit epithelial defects in 39% of cases.

      (Pilot et al., 2006)
      External Data
      Interactions
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      btszK13-4
      (Maybeck and Röper, 2009, Pilot, 2006, Pilot et al., 2006)
      btszk13-4
      (Tsarouhas et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)