FlyBase Allele Report: Dmel\klg[E226]

General Information

Symbol

Dmel\klg^E226

Species

D. melanogaster

Name

FlyBase ID

FBal0057231

Feature type

allele

Associated gene

Dmel\klg

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Butler et al., 1997)

Mutagen

P-element activity

(Butler et al., 1997)

Progenitor genotype

klg^H214

(Butler et al., 1997)

Cytology

Description

The klg ORF is entirely deleted in the klg^E226 mutation, although the 3' end of the deletion has not been determined.

(Matsuno et al., 2009)

Imprecise excision of the P{HZ} element, resulting in a deletion (extending in both directions from the site of the P{HZ} element insertion) that removes the entire klg open reading frame.

(Butler et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory (with klg^GS10439)

(Matsuno et al., 2009)

abnormal memory (with klg^ruslan)

(Matsuno et al., 2009)

lethal | recessive

(Butler et al., 1997)

lethal - all die before end of larval stage | recessive

(Matsuno et al., 2009)

some die during larval stage | recessive

(Matsuno et al., 2009)

viable (with klg^GS10439)

(Matsuno et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

1-day memory after spaced training is disrupted in klg^GS10439/klg^E226 and klg^ruslan/klg^E226 flies.

(Matsuno et al., 2009)

Homozygotes die as second instar larvae. The overall structure of the embryonic central nervous system develops normally. Homozygous clones in the eye show no alteration in the number or morphology of the photoreceptors.

(Butler et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

klg^E226/klg^GS10439 is a suppressor of abnormal memory | heat sensitive phenotype of N^Hsp70Bb.PL

(Matsuno et al., 2009)

Phenotype Manifest In

Other

Statement

Reference

Sos^JC2, klg^E226, sev⁶ has ommatidium phenotype

(Butler et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

The enhancement of long-term memory by N^Hsp70Bb.PL over-expression is suppressed in klg^GS10439/klg^E226 flies.

(Matsuno et al., 2009)

Reduces the proportion of ommatidia containing an R7 cell in sev⁶/Y ; Sos^JC2/+ flies.

(Butler et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

klg^E226/klg^GS10439 is partially rescued by Scer\GAL4^hs.PB, klg^GS10439

(Matsuno et al., 2009)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(3R)E226

(Butler et al., 1997)

E226

(Duan et al., 2001)

klg^E226

(Matsuno et al., 2019, Matsuno et al., 2015, Matsuno et al., 2009)

klg^EY226

(Koper et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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