FlyBase Allele Report: Dmel\klg[GS10439]

General Information

Symbol

Dmel\klg^GS10439

Species

D. melanogaster

Name

FlyBase ID

FBal0195065

Feature type

allele

Associated gene

Dmel\klg

Associated Insertion(s)

P{GSV6}klg^GS10439

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

P{GSV6}klg^GS10439

Cytology

Description

The klg^GS10439 mutation results from an insertion of a P-UAS transposon 75 bp upstream of the proposed transcription start site.

(Matsuno et al., 2009)

Insertion oriented to drive expression in the sense direction starting upstream of the coding region.

(Gregory et al., 2007)

Allele components

Component

Use(s)

Inserted element

P{GSV6}

misexpression element

Regulatory region(s)

UASt

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:22,899,227..22,899,227

(Matsuno et al., 2009, Gregory et al., 2007)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal memory (with klg^E226)

(Matsuno et al., 2009)

lethal - all die before end of larval stage | recessive

(Matsuno et al., 2009)

some die during larval stage | recessive

(Matsuno et al., 2009)

viable (with klg^E226)

(Matsuno et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

1-day memory after spaced training is disrupted in heterozygous klg^GS10439/klg^E226 flies.

The klg^GS10439 mutation is recessive for impaired memory.

(Matsuno et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

klg^E226/klg^GS10439 is a suppressor of abnormal memory | heat sensitive phenotype of N^Hsp70Bb.PL

(Matsuno et al., 2009)

klg^GS10439/Scer\GAL4^GMR.PF is a suppressor | partially of visible phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Phenotype Manifest In

Suppressor of

Statement

Reference

klg^GS10439/Scer\GAL4^GMR.PF is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PF, pbl^{ΔDH497-549.UAS}

(Gregory et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

The enhancement of long-term memory by N^Hsp70Bb.PL over-expression is suppressed in klg^GS10439/klg^E226 flies.

(Matsuno et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

klg^ruslan/klg^GS10439 is rescued by Scer\GAL4^klg-ruslan, klg^GS10439

(Matsuno et al., 2009)

Partially rescued by

klg^E226/klg^GS10439 is partially rescued by Scer\GAL4^hs.PB, klg^GS10439

(Matsuno et al., 2009)

Rescues

Scer\GAL4^klg-ruslan, klg^GS10439 rescues klg^ruslan/klg^GS10439

(Matsuno et al., 2009)

Partially rescues

Scer\GAL4^hs.PB, klg^GS10439 partially rescues klg^E226/klg^GS10439

(Matsuno et al., 2009)

Comments

The Scer\GAL4^klg-ruslan driver in klg^ruslan induces Scer\UAS dependent klg expression in klg^GS10439 leading to the rescue of the long-term memory defects in klg^ruslan/klg^GS10439 flies.

1-day memory after spaced training improved significantly in heat-shocked Scer\GAL4^hs.PB/+; klg^GS10439/klg^E226 flies.

(Matsuno et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

klg^GS10439

(Matsuno et al., 2019, Matsuno et al., 2015, Matsuno et al., 2009)

klg^GS

(Matsuno et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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