FlyBase Allele Report: Dmel\CrebA[rR7]

General Information

Symbol

Dmel\CrebA^rR7

Species

D. melanogaster

Name

FlyBase ID

FBal0059179

Feature type

allele

Associated gene

Dmel\CrebA

Associated Insertion(s)

P{PZ-ΔrR7}CrebA^rR7

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

Nature of the Allele

Allele class

loss of function allele

(Andrew et al., 1997)

Mutagen

P-element activity

(Andrew et al., 1997)

Delta2-3 transposase

(Rose et al., 1997)

Progenitor genotype

CrebA⁰³⁵⁷⁶

(Andrew et al., 1997, Rose et al., 1997)

Associated Insertion(s)

P{PZ-ΔrR7}CrebA^rR7

Cytology

Description

Loss of a few hundred bp of DNA from the transcribed region.

(Andrew et al., 1997)

Deletion, leaving part of the P{PZ} element intact.

(Rose et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | recessive

(Andrew et al., 1997)

lethal - all die during embryonic stage | recessive

(Rose et al., 1997)

some die during embryonic stage | recessive

(Rose et al., 1997)

some die during larval stage | recessive

(Andrew et al., 1997)

Phenotype Manifest In

embryonic/larval cuticle

(Andrew et al., 1997)

larva

(Andrew et al., 1997)

ventral denticle belt | larval stage

(Andrew et al., 1997)

Detailed Description

Statement

Reference

Homozygous larvae are 40% the length and the same width as their heterozygous siblings, length differences arise during larva formation as embryos are about the same length as their heterozygous siblings. The larval cuticle of homozygotes is weak, as seen by frequent holes at random positions in the exoskeleton. The dorsal and ventral larval cuticle is composed of pattern elements found in the ventrolateral position in the wild-type larval cuticle. In dpp^H48; CrebA^wR7 and dpp^BP.hs; CrebA^wR7 larvae the entire cuticle is lateralised (dpp^H48 larval cuticle is ventralised).

(Andrew et al., 1997)

CrebA^rR7/Df(3L)BK10 animals die as embryos.

(Rose et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(3L)BK10/CrebA^rR7 is rescued by CrebA^UAS.cRa/Scer\GAL4^hs.PB

(Rose et al., 1997)

Comments

The lethality of CrebA^rR7/Df(3L)BK10 is rescued by CrebA^Scer\UAS.cRa expressed under the control of Scer\GAL4^hs.PB using heat shock.

(Rose et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CrebA^rR7

dCREB-A^R7

(Andrew et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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