FlyBase Allele Report: Dmel\pyd[J14]

General Information

Symbol

Dmel\pyd^J14

Species

D. melanogaster

Name

FlyBase ID

FBal0059953

Feature type

allele

Associated gene

Dmel\pyd

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

gamma ray

Nature of the Allele

Allele class

Mutagen

gamma ray

(Chen et al., 1996)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Chen et al., 1996)

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Chen et al., 1996)

Phenotype Manifest In

cephalopharyngeal skeleton

(Chen et al., 1996)

cone cell

(Chen et al., 1996)

eye

(Chen et al., 1996)

macrochaeta

(Chen et al., 1996)

ommatidium

(Chen et al., 1996)

primary pigment cell

(Chen et al., 1996)

sensory mother cell

(Chen et al., 1996)

ventral denticle belt

(Chen et al., 1996)

Detailed Description

Statement

Reference

pyd^J14/pyd^J14, pyd^J14/Df(3R)pydC2 and pyd^J14/pyd^C5 flies have extra macrochaetae on the head and notum compared to wild-type. Heterozygotes have an average of 0.29 +/- 0.07 extra macrochaetae per fly. Late third instar larval discs contain extra sensory organ precursors. Homozygotes have slightly rough eyes, due to the presence of duplicated and mispositioned bristles and occasional enlarged and irregularly shaped ommatidia. Ommatidia occasionally contain too few or extra cone cells and/or extra primary pigment cells. A small fraction of hemizygous embryos fail to hatch. These embryos show some defects in head involution and head skeleton formation, and denticle belts are sparse and disorganised.

(Chen et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

emc²⁰, pyd^J14 has lethal | recessive phenotype

(Chen et al., 1996)

Phenotype Manifest In

Enhanced by

Statement

Reference

pyd^J14 has sense organ phenotype, enhanceable by emc²⁰

(Chen et al., 1996)

pyd^J14 has cephalopharyngeal skeleton phenotype, enhanceable by emc²⁰

(Chen et al., 1996)

pyd^J14 has ventral denticle belt phenotype, enhanceable by emc²⁰

(Chen et al., 1996)

pyd^J14 has embryonic/first instar larval cuticle | dorsal phenotype, enhanceable by emc²⁰

(Chen et al., 1996)

pyd^J14 has macrochaeta phenotype, enhanceable by Delta^6B

(Chen et al., 1996)

pyd^J14 has eye phenotype, enhanceable by Delta^6B

(Chen et al., 1996)

Suppressor of

Statement

Reference

pyd^J14 is a suppressor of macrochaeta phenotype of N^Ax-E2

(Chen et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The pyd^J14 extra bristle and rough eye phenotypes are strongly enhanced by Dl^6B at 29^oC. The bristle loss phenotype of N^Ax-E2/+ flies is partially suppressed by pyd^J14. One copy of emc²⁰ strongly enhances the pyd^J14 phenotype, resulting in extra sensory organs in positions characteristic of pyd mutants rather than emc mutants. emc²⁰ pyd^J14 double homozygotes die as embryos or early larvae. The embryos produced usually have severe defects in head involution and lack the cephalo-pharyngeal skeleton. Some embryos also have holes in the dorsal cuticle of the head. The denticle belts are sparse and disorganised.

(Chen et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pyd^tam

(Wei and Ellis, 2001)

Rescued by

pyd^C5/pyd^J14 is rescued by pyd^hs.PT/pyd^6-.hs

(Wei and Ellis, 2001)

Partially rescued by

pyd^C5/pyd^J14 is partially rescued by pyd^hs.PT

(Wei and Ellis, 2001)

pyd^C5/pyd^J14 is partially rescued by pyd^6-.hs

(Wei and Ellis, 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Order of alleles based on increasing severity of phenotype when hemizygous: pyd¹ < pyd^J17 < pyd^J4 = pyd^J2 < pyd^G18 = pyd^G7 < pyd^J14 = pyd^C5.

(Chen et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

pyd^J14

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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