FlyBase Allele Report: Dmel\pyd[tam]

General Information

Symbol

Dmel\pyd^tam

Species

D. melanogaster

Name

FlyBase ID

FBal0051070

Feature type

allele

Associated gene

Dmel\pyd

Associated Insertion(s)

P{BmΔ-w}pyd^tam

Carried in Construct

Also Known As

pyd^tam1, pyd^tamou

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Takahisa et al., 1996)

Mutagen

Delta2-3 transposase

(Takahisa et al., 1996)

Progenitor genotype

Associated Insertion(s)

P{BmΔ-w}pyd^tam

Cytology

Description

P{BmΔ-w} insertion just 5' to the first (non-coding) exon.

(Takahisa et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:8,846,373..8,846,373 [-]

(Seppa et al., 2008, Takahashi et al., 1998, Takahisa et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female fertile

(Takahisa et al., 1996)

increased cell number (with Df(3R)p-XT103)

(Djiane et al., 2011)

male fertile

(Takahisa et al., 1996)

viable

(Takahisa et al., 1996)

visible (with Df(3R)p-XT103)

(Djiane et al., 2011)

visible (with pyd^C5)

(Djiane et al., 2011)

visible (with pyd^ex147)

(Djiane et al., 2011)

Phenotype Manifest In

dorsocentral bristle | increased number (with Df(3R)p-XT103)

(Djiane et al., 2011)

dorsocentral bristle | increased number (with pyd^C5)

(Djiane et al., 2011)

germarium cap cell | increased number

(Djiane et al., 2011)

macrochaeta & adult head | dorsal

(Takahisa et al., 1996)

macrochaeta & adult thorax | dorsal

(Takahisa et al., 1996)

wing (with pyd^ex147)

(Djiane et al., 2011)

wing sensillum

(Takahisa et al., 1996)

Detailed Description

Statement

Reference

70% of pyd^tam/pyd^C5 flies display more than four dorsocentral macrochaetae.

Over 80% of pyd^tam/Df(3R)p-XT103 flies display more than four dorsocentral macrochaetae.

Wings from pyd^tam/Df(3R)p-XT103 flies are broader compared to control wings. A 5-10% increase in the number of cells found between the L3 and L4 veins is observed.

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings.

pyd^tam mutants display an increase in the number of ovarian niche cap cells.

(Djiane et al., 2011)

Homozygous embryos develop normally. Homozygous adults have a normal dorsal thorax. Homozygous hep¹ adults show slight widening of the dorsal thorax.

(Takahashi et al., 1998)

Ectopic macrochaetae are present on the dorsal surface of the adult head and thorax. Extra sensilla campaniformia develop on the wing vein.

(Takahisa et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

pyd^tam/pyd^ex147 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Djiane et al., 2011)

Enhancer of

Statement

Reference

pyd^tam is an enhancer of visible | recessive phenotype of hep¹

(Takahashi et al., 1998)

NOT Enhancer of

Statement

Reference

pyd^tam/pyd[+] is a non-enhancer of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

pyd^tam/pyd[+] is a non-suppressor of visible | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

cno^mis1, pyd^tam has lethal | dominant phenotype

(Takahashi et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

pyd^C5/pyd^tam has dorsocentral bristle | increased number phenotype, enhanceable by N[+]/N^55e11

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, enhanceable by ex[+]/ex^e1

(Djiane et al., 2011)

NOT Enhanced by

Statement

Reference

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Cdk4³/Cdk4[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Cdk4^k06503/Cdk4[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Tor[+]/mTor^ΔP

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Pten^dj189/Pten[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Pten^c494/Pten[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Su(dx)^sp/Df(2L)Exel6006

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by N[+]/N^55e11

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Su(H)⁸/Su(H)[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by Su(dx)^sp/Su(dx)[+]

(Djiane et al., 2011)

pyd^tam/pyd^ex147 has wing phenotype, non-enhanceable by yps[+]/yps^JM2

(Djiane et al., 2011)

pyd^tam has phenotype, non-enhanceable by a⁷/Df(2R)a^EX1

(Liu and Lengyel, 2000)

NOT suppressed by

Statement

Reference

pyd^tam has phenotype, non-suppressible by a⁷/Df(2R)a^EX1

(Liu and Lengyel, 2000)

Enhancer of

Statement

Reference

pyd^tam is an enhancer of adult thorax | dorsal phenotype of hep¹

(Takahashi et al., 1998)

pyd^tam is an enhancer of adult thorax & adult cuticle | dorsal phenotype of hep¹

(Takahashi et al., 1998)

NOT Enhancer of

Statement

Reference

pyd^tam/pyd[+] is a non-enhancer of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

NOT Suppressor of

Statement

Reference

pyd^tam/pyd[+] is a non-suppressor of eye | adult stage phenotype of Magi^UAS.GFP, Scer\GAL4^GMR.PU

(Zaessinger et al., 2015)

Other

Statement

Reference

cno^mis1, pyd^tam/pyd[+] has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

cno^mis1/cno[+], pyd^tam has embryonic/first instar larval cuticle phenotype

(Takahashi et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

The rough eye phenotype observed in adults expressing Magi^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^GMR.PU is not modified by combination with single copy of pyd^tam.

(Zaessinger et al., 2015)

100% of N^55e11/+; pyd^tam/pyd^C5 flies display more than four dorsocentral macrochaetae.

The broader wings observed in pyd^ex147/pyd^tam flies are not enhanced in a N^55e11/+ background.

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is enhanced in a ex^e1/+ background.

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Su(H)⁸/+, Su(dx)^sp/+, yps^JM2/+, Cdk4³/+, Cdk4^k06503/+, Tor^ΔP/+, Pten^dj189/+, or Pten^c494/+ background.

Wings from pyd^ex147/pyd^tam flies are broader compared to control wings, and this phenotype is not modified in a Su(dx)^sp/Df(2L)Exel6006 background.

(Djiane et al., 2011)

The addition of pyd^tam/+ has no effect on a⁷/Df(2R)a^EX1 flies.

(Liu and Lengyel, 2000)

pyd^tam cno^mis1 double heterozygotes die as embryos with a dorsal open phenotype. The leading edge cells show little elongation during stage 15 (at or slightly before completion of dorsal closure). The dorsal thoracic cuticle of hep¹ homozygous adults is severely disrupted in a pyd^tam homozygous background.

(Takahashi et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

pyd^J14

(Wei and Ellis, 2001)

Rescued by

pyd^tam/pyd^ex147 is rescued by Scer\GAL4^Act5C.PU/pyd^UAS.GFP

(Djiane et al., 2011)

pyd^tam/pyd^ex147 is rescued by pyd^{ΔEx6.UAS.GFP}/Scer\GAL4^Act5C.PU

(Djiane et al., 2011)

pyd^tam/pyd^ex147 is rescued by Scer\GAL4^Act5C.PU/pyd^{ΔPDZ1.UAS.GFP}

(Djiane et al., 2011)

pyd^tam/pyd^ex147 is rescued by Scer\GAL4^Act5C.PU/pyd^{ΔSH3.UAS.GFP}

(Djiane et al., 2011)

pyd^C5/pyd^tam is rescued by pyd^UAS.GFP/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

pyd^C5/pyd^tam is rescued by Scer\GAL4^sca-537.4/pyd^{ΔPDZ1.UAS.GFP}

(Djiane et al., 2011)

pyd^tam is rescued by pyd^hs.PT

(Takahisa et al., 1996)

Partially rescued by

pyd^tam/pyd^ex147 is partially rescued by Scer\GAL4^Act5C.PU/pyd^{ΔPDZ3.UAS.GFP}

(Djiane et al., 2011)

pyd^C5/pyd^tam is partially rescued by pyd^{ΔPro-Rich.UAS.GFP}/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

pyd^C5/pyd^tam is partially rescued by pyd^{ΔSH3.UAS.GFP}/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

Not rescued by

pyd^tam/pyd^ex147 is not rescued by Scer\GAL4^Act5C.PU/pyd^{ΔPro-Rich.UAS.GFP}

(Djiane et al., 2011)

pyd^tam/pyd^ex147 is not rescued by Scer\GAL4^Act5C.PU/pyd^{ΔPDZ2.UAS.GFP}

(Djiane et al., 2011)

pyd^tam/pyd^ex147 is not rescued by Scer\GAL4^Act5C.PU/pyd^{ΔGUK.UAS.GFP}

(Djiane et al., 2011)

pyd^C5/pyd^tam is not rescued by pyd^{ΔEx6.UAS.GFP}/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

pyd^C5/pyd^tam is not rescued by Scer\GAL4^sca-537.4/pyd^{ΔPDZ2.UAS.GFP}

(Djiane et al., 2011)

pyd^C5/pyd^tam is not rescued by pyd^{ΔPDZ3.UAS.GFP}/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

pyd^C5/pyd^tam is not rescued by pyd^{ΔGUK.UAS.GFP}/Scer\GAL4^sca-537.4

(Djiane et al., 2011)

Comments

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is reduced when pyd^{Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is reduced when pyd^{ΔPDZ1.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is not reduced when pyd^{ΔPDZ2.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is not reduced when pyd^{ΔPDZ3.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is not reduced when pyd^{ΔGUK.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is not reduced when pyd^{ΔEx6.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4. A more severe bristle phenotype is observed in these animals.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is partially reduced when pyd^{ΔSH3.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The number of pyd^tam/pyd^C5 flies displaying an increased number of dorsocentral macrochaete is partially reduced when pyd^{ΔPro-Rich.Scer\UAS.T:Avic\GFP} is expressed under the control of Scer\GAL4^sca-537.4.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is restored in animals expressing pyd^{Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is restored in animals expressing pyd^{ΔPDZ1.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is restored in animals expressing pyd^{ΔEx6.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is not restored in animals expressing pyd^{ΔPDZ2.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is not restored in animals expressing pyd^{ΔSH3.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is not restored in animals expressing pyd^{ΔGUK.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is not restored in animals expressing pyd^{ΔPro-Rich.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

The increased size of adult wings in pyd^ex147/pyd^tam mutant flies is partially restored in animals expressing pyd^{ΔPDZ3.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^Act5C.PU.

(Djiane et al., 2011)

pyd^hs.PT rescues the extra bristle phenotype of pyd^tam.

(Takahisa et al., 1996)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

109030

P{BmΔ-w}cno^mis1 P{BmΔ-w}pyd^tam / TM3, P{ftz-lacZ.ry⁺}TM3, Sb¹ ry^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

pyd^tam1

(Shimizu et al., 2017, Choi et al., 2011, Seppa et al., 2008, Liu and Lengyel, 2000, Takahashi et al., 1998)

pyd^tam

(Goossens et al., 2011)

pyd^tamou

(Zaessinger et al., 2015, Djiane et al., 2011)

tam¹

(Wei and Ellis, 2001)

Name Synonyms

Secondary FlyBase IDs

References (10)

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