FB2024_03 , released June 25, 2024
Allele: Dmel\CrebBCbz.UAS
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General Information
Symbol
Dmel\CrebBCbz.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060750
Feature type
allele
Associated gene
Dmel\CrebB
Associated Insertion(s)
Carried in Construct
P{Cbz}
Also Known As
UAS-CREBDN
Key Links
Transgenic product class
dominant_negative_variant
(Eresh et al., 1997)
inframe_deletion
(Eresh et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Eresh et al., 1997)
inframe_deletion
(Eresh et al., 1997)
Mutagen
in vitro construct
(Eresh et al., 1997)
Progenitor genotype
Carried in construct
P{Cbz}
Cytology
Description

UASt regulatory sequences drive expression of amino acids 223-285 (the bZIP region) of CrebB. The protein is expected to act as a dominant negative.

(Eresh et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
CrebB
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of CrebBCbz.UAS in Crz neurons under the control of Scer\GAL4CrzR.3.5.PS results in flies that show a significantly delayed recovery from ethanol-induced sedation.

      (Sha et al., 2014)

      When expression is driven by Scer\GAL448Y the number of copper cells is reduced. The effect is similar to, but less extreme than that seen with kayFbz.Scer\UAS. When expression is driven by Scer\GAL4hs.PB lethality results.

      (Riese et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      CrebBCbz.UAS, Scer\GAL430A is a non-enhancer of wing phenotype of Pka-C1UAS.cKa, Scer\GAL430A

      (Kiger et al., 2001)
      NOT Suppressor of
      Statement
      Reference

      CrebBCbz.UAS, Scer\GAL430A is a non-suppressor of wing phenotype of Pka-C1UAS.cKa, Scer\GAL430A

      (Kiger et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The increase in food consumption compared to controls seen in adults expressing sNPF-RScer\UAS.cLa under the control of Scer\GAL4sNPF-R.2.5 is suppressed by co-expression of CrebBCbz.Scer\UAS.

      (Hong et al., 2012)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Protein acts as a dominant negative as the bZIP domain is able to dimerize and bind DNA without being able to stimulate transcription.

      (Eresh et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      CrebB-17ACbz.Scer\UAS
      CrebB-17ACbz.UAS
      CrebBCbz.Scer\UAS
      CrebBCbz.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (9)