FB2024_03 , released June 25, 2024
Allele: Dmel\Nop60Bk06308
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General Information
Symbol
Dmel\Nop60Bk06308
Species
D. melanogaster
Name
FlyBase ID
FBal0064498
Feature type
allele
Associated gene
Dmel\Nop60B
Associated Insertion(s)
P{lacW}Nop60Bk06308
Carried in Construct
Also Known As
l(2)k06308
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(BDGP Project Members, 1994-1999)
Progenitor genotype
Associated Insertion(s)
P{lacW}Nop60Bk06308
Cytology
Description

P{PZ} insertion at the 5' end of the gene.

(Giordano et al., 1999)

P{lacW} is inserted 25 bp upstream of the start of the longest Nop60B cDNA clone.

(Phillips et al., 1998)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes either die as second or mainly as early third instar larvae. They fail to increase their size compared to control siblings and remain as second or third instar larvae for an additional 4-5 days.

      (Giordano et al., 1999)

      Pupae show no obvious developmental defect.

      (Phillips et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Nop60B1

      (Giordano et al., 1999)

      Nop60Bk05318

      (BDGP Project Members, 1994-1999)
      Partially rescued by

      Nop60Bk06308 is partially rescued by Nop60Bhs.PG

      (Giordano et al., 1999)
      Comments

      Expression of Nop60Bhs.PG using heat shock rescues 80% of Nop60Bk06308 animals to the pupal stage. The rescued animals develop synchronously with their control siblings and show a normal increase in size.

      (Giordano et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      I. Kiss.

      (BDGP Project Members, 1994-1999)
      Comments
      Comments

      Complements: eIF-5A01296. Complements: spagk12101. Complements: Zfrp8k13705.

      (BDGP Project Members, 1994-1999)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Nop60Bk06308
      l(2)k05318k06308
      l(2)k06308
      (Giordano et al., 1999, Spradling et al., 1999)
      mfl06
      (Giordano et al., 1999)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)