FlyBase Allele Report: Dmel\bif[R47]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\bif^R47

General Information

Symbol

Dmel\bif^R47

Species

D. melanogaster

Name

FlyBase ID

FBal0064945

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Bahri et al., 1997)

Progenitor genotype

P{wA^R}PhKγ^P842

(Bahri et al., 1997)

Cytology

Description

Deletion in bif, removing 3kb of exon 3 and a second deletion removing most of exon 6.

(Bahri et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Ruan et al., 2002)

abnormal neuroanatomy | third instar larval stage

(Kurusu and Zinn, 2008)

visible | recessive

(Helps et al., 2001)

Phenotype Manifest In

(Helps et al., 2001)

embryonic/larval optic lobe

(Babu et al., 2005)

interommatidial bristle

(Helps et al., 2001)

interommatidial bristle | increased number

(Helps et al., 2001)

(Ruan et al., 2002)

medial lobe of larval mushroom body | third instar larval stage

(Kurusu and Zinn, 2008)

(Helps et al., 2001)

photoreceptor cell R1 & axon

(Babu et al., 2005, Ruan et al., 2002)

photoreceptor cell R2 & axon

(Babu et al., 2005, Ruan et al., 2002)

photoreceptor cell R3 & axon

(Babu et al., 2005, Ruan et al., 2002)

photoreceptor cell R4 & axon

(Babu et al., 2005, Ruan et al., 2002)

photoreceptor cell R5 & axon

(Babu et al., 2005, Ruan et al., 2002)

photoreceptor cell R6 & axon

(Ruan et al., 2002)

photoreceptor cell R7 & axon

(Ruan et al., 2002)

photoreceptor cell R8 & axon

(Ruan et al., 2002)

(Babu et al., 2005, Helps et al., 2001)

Detailed Description

Statement

Reference

The R2-R5 axons in bif^R47 mutant larvae bypass the lamina, to which they are targeted in wild-type optic lobes, and terminate in the medulla. Breaks are detectable in the lamina surface of these mutants but the optic lobe shows no gross abnormalities. bif^R47 mutant adult brains show largely normal arrays of axons, although the rhabdomeres of the retina have defective morphology.

(Babu et al., 2005)

Gaps are frequently seen in the R1-R6 growth cone termination site in bif^R47/Y larvae, and many axons project through the lamina into the medulla layer. The R7 projection pattern is indistinguishable from that in wild type.

(Ruan et al., 2002)

Homozygous eyes have bristles that are short, missing or duplicated. Fusion of adjacent ommatidia is occasionally seen. The majority of rhabdomeres are elliptical (they are round in wild-type flies) and most ommatidia show irregular patterns in the spatial organisation of the rhabdomeres. F-actin distribution in the pupal eye disc is abnormal.

(Helps et al., 2001)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

bif^R47 has abnormal neuroanatomy | third instar larval stage phenotype, non-enhanceable by Df(1)Δ59

(Kurusu and Zinn, 2008)

NOT suppressed by

Statement

Reference

bif^R47 has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Df(1)Δ59

(Kurusu and Zinn, 2008)

Suppressor of

Statement

Reference

bif[+]/bif^R47 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Df(2L)Prl, bif^R47 has visible | recessive phenotype

(Bahri et al., 1997)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

bif^R47 has medial lobe of larval mushroom body | third instar larval stage phenotype, non-enhanceable by Df(1)Δ59

(Kurusu and Zinn, 2008)

NOT suppressed by

Statement

Reference

bif^R47 has medial lobe of larval mushroom body | third instar larval stage phenotype, non-suppressible by Df(1)Δ59

(Kurusu and Zinn, 2008)

Suppressor of

Statement

Reference

bif[+]/bif^R47 is a suppressor of photoreceptor cell & axon phenotype of Scer\GAL4^GMR.PF, msn^EP549

(Ruan et al., 2002)

Other

Statement

Reference

Ptp10D¹, bif[+]/bif^R47 has embryonic/larval optic lobe phenotype

(Babu et al., 2005)

Ptp69D¹, bif[+]/bif^R47 has embryonic/larval optic lobe phenotype

(Babu et al., 2005)

Pp1-87B[+]/Pp1-87B^unspecified, bif^R47 has photoreceptor cell R1 & axon phenotype

(Babu et al., 2005)

Pp1-87B[+]/Pp1-87B^unspecified, bif^R47 has photoreceptor cell R2 & axon phenotype

(Babu et al., 2005)

Pp1-87B[+]/Pp1-87B^unspecified, bif^R47 has photoreceptor cell R3 & axon phenotype

(Babu et al., 2005)

Pp1-87B[+]/Pp1-87B^unspecified, bif^R47 has photoreceptor cell R4 & axon phenotype

(Babu et al., 2005)

Pp1-87B[+]/Pp1-87B^unspecified, bif^R47 has photoreceptor cell R5 & axon phenotype

(Babu et al., 2005)

bif^R47, homer^LL17 has oocyte phenotype

(Babu et al., 2004)

Df(2L)Prl, bif^R47 has eye phenotype

(Bahri et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

bif^R47/+; Pp1-87B^unspecified/+ double mutant larvae show mistargeting of axons R2-R5 into the medulla and clumping of axons in the lamina. Neither single heterozygote shows this phenotype.

bif^R47/+; Ptp10D¹/+ and bif^R47/+; Ptp69D¹/+ double mutants and show clumps and breaks in the lamina, while neither single heterozygote shows this phenotype.

(Babu et al., 2005)

bif^R47/homer^LL17 mutants exhibit severe defects in the anchoring of osk RNA and proteins at the posterior of the developing oocyte. The F-actin cytoskeleton in these mutants are indistinguishable from wild-type. Polarity of microtubules appears normal and the cytoskeleton-dependant cytoplasmic streaming occurs normally. Treating these oocytes with an actin depolymerisation drug does not exacerbate the phenotype. When bif^R47 single mutant oocytes are treated with an actin depolymerisation drug osk anchoring is defective.

(Babu et al., 2004)

The defects in photoreceptor cell projection patterns seen in larvae overexpressing msn^EP549 under the control of Scer\GAL4^GMR.PF are largely suppressed by one copy of bif^R47.

(Ruan et al., 2002)

bif^R47/Y ; Df(2L)Prl/+ flies have rough eyes.

(Bahri et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

bif^R47 is rescued by Scer\GAL4^GMR.PF/bif^UAS.cHa

(Babu et al., 2005)

Partially rescued by

bif^R47 is partially rescued by Scer\GAL4^GMR.PF/bif^UAS.cHa

(Helps et al., 2001)

Not rescued by

bif^R47 is not rescued by bif^F995A.UAS/Scer\GAL4^GMR.PF

(Babu et al., 2005)

bif^R47 is not rescued by bif^F995A.UAS/Scer\GAL4^GMR.PF

(Helps et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

R47

(Bahri et al., 1997)

bif^R47

(Mathew et al., 2011, Kurusu and Zinn, 2008, Babu et al., 2005)

bifR47

(Babu et al., 2004, Babu et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections