FB2024_03 , released June 25, 2024
Allele: Dmel\homerLL17
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General Information
Symbol
Dmel\homerLL17
Species
D. melanogaster
Name
FlyBase ID
FBal0155200
Feature type
allele
Associated gene
Dmel\homer
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Babu et al., 2004)
Mutagen
P-element activity
(Babu et al., 2004)
Progenitor genotype
P{EP}homerEP2141
(Babu et al., 2004)
Cytology
Description

Imprecise excision of the P{EP}EP2141 element, deletes the entire homer coding region.

(Babu et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      bifR47, homerLL17 has oocyte phenotype

      (Babu et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      bifR47/homerLL17 mutants exhibit severe defects in the anchoring of osk RNA and proteins at the posterior of the developing oocyte. The F-actin cytoskeleton in these mutants are indistinguishable from wild-type. Polarity of microtubules appears normal and the cytoskeleton-dependant cytoplasmic streaming occurs normally. Treating these oocytes with an actin depolymerisation drug does not exacerbate the phenotype. When bifR47 single mutant oocytes are treated with an actin depolymerisation drug osk anchoring is not affected.

      (Babu et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      homLL17
      (Babu et al., 2004, Babu et al., 2004)
      homerLL17
      Name Synonyms
      Secondary FlyBase IDs
        References (2)