FB2024_03 , released June 25, 2024
Allele: Mmus\Map2k7Ubi-p63E.PH
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General Information
Symbol
Mmus\Map2k7Ubi-p63E.PH
Species
M. musculus
Name
Ubiquitin-63E promoter construct of Holland
FlyBase ID
FBal0066013
Feature type
allele
Associated gene
Mmus\Map2k7
Associated Insertion(s)
Carried in Construct
P{Mmus\Mkk7Ubi-p63E.PH}
Transgenic product class
wild_type
(Holland et al., 1997)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Holland et al., 1997)
Mutagen
in vitro construct
(Holland et al., 1997)
Progenitor genotype
Carried in construct
P{Mmus\Mkk7Ubi-p63E.PH}
Cytology
Description

A 1.3kb EcoRI fragment encoding the 'a' alternative splice variant of Mmus\Map2k7 is expressed under the control of a Ubi-p63E promoter.

(Holland et al., 1997)
Allele components
Component
Use(s)
Regulatory region(s)
Ubi-p63E
Encoded product / tool
Mmus\Map2k7
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rescues the lethality of heprh1 and heprh99 males in 42% and 62% of cases respectively. Some of the males produced are fully fertile and viable, but the majority of adult males have defects in the dorsal thorax and in the development and rotation of the anal plate and genital arches. Does not significantly rescue the lethality of hepr39, hepr45, hepr51, hepr75, heprh8, heprh19 or heprh31 hemizygous males. Does not rescue the lethality of Dsor1r1 hemizygous males.

      (Holland et al., 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Mmus\Map2k7Ubi-p63E.PH is a suppressor of lethal | recessive phenotype of heprh99

      (Holland et al., 1997)
      NOT Suppressor of
      Statement
      Reference

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal | recessive phenotype of Dsor1r1

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of hepr39

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of hepr45

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of hepr51

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of hepr75

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of heprh19

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of heprh31

      (Holland et al., 1997)

      Mmus\Map2k7Ubi-p63E.PH is a non-suppressor of lethal phenotype of heprh8

      (Holland et al., 1997)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Mmus\Map2k7Ubi-p63E.PH
      Mmus\Mkk7Ubi-p63E.PH
      Mmus\Prkmk7Ubi-p63E.PH
      Name Synonyms
      Ubiquitin-63E promoter construct of Holland
      (Holland et al., 1997)
      Secondary FlyBase IDs
        References (1)