FB2024_03 , released June 25, 2024
Allele: Dmel\encR17
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General Information
Symbol
Dmel\encR17
Species
D. melanogaster
Name
FlyBase ID
FBal0082945
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Cytology
Description

Excision of the P{lArB} element in encA309.1M3, removing sequence upstream of the original insertion, while leaving downstream sequences intact.

Imprecise excision of the P{lArB} element present in encA309.1M3.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Mutant egg chambers show defects in karyosome morphology; often the nuclear material is split into two or three lobes. No extra round of germline mitosis is seen in mutant females.

Eggs derived from hemizygous females show a cold-sensitive ventralised egg-shell phenotype. At 18oC, 79% of eggs produced by hemizygous females have a single dorsal appendage and 20% of the egg shells have a further reduction in dorsal appendage material. None of the eggs laid at this temperature hatch. In contrast, at 25oC, 97% of eggs produced by hemizygous females have a wild-type egg shell, and only 3% possess a single dorsal appendage. 29% of the eggs hatch at this temperature. Embryos derived from hemizygous females are variably ventralised. They frequently have a ventral hole centered around abdominal segments A4-A6. In some embryos this hole extends along the entire abdominal region, though in many embryos the head skeleton is still completely intact. The most severely affected embryos have a completely ventralised cuticle, and all structures posterior to A8 are missing, including posterior spiracles, Filzkorper and anal pads.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement
Reference

encR17 has karyosome phenotype, non-suppressible by mei-41D3

encR17 has egg chorion phenotype, non-suppressible by mei-41D3

Additional Comments
Genetic Interactions
Statement
Reference

The egg shell ventralisation and karyosome defects seen in hemizygous encR17 females are not suppressed by mei-41D3.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
encR17
Name Synonyms
Secondary FlyBase IDs
    References (2)