FlyBase Allele Report: Dmel\S[unspecified]

General Information

Symbol

Dmel\S^unspecified

Species

D. melanogaster

Name

FlyBase ID

FBal0086767

Feature type

allele

Associated gene

Dmel\S

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Neufeld et al., 1998)

X ray

(Neufeld et al., 1998)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Therrien et al., 2000)

lethal - all die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

some die during embryonic stage | recessive

(Tearle and Nusslein-Volhard, 1987)

visible | dominant

(Rousso et al., 2010, Tearle and Nusslein-Volhard, 1987)

Phenotype Manifest In

anal pad

(Tearle and Nusslein-Volhard, 1987)

cephalopharyngeal skeleton

(Tearle and Nusslein-Volhard, 1987)

embryonic ventral nerve cord

(Tearle and Nusslein-Volhard, 1987)

eye

(Rousso et al., 2010, Tearle and Nusslein-Volhard, 1987)

Keilin organ

(Tearle and Nusslein-Volhard, 1987)

larval longitudinal connective

(Hummel et al., 1999)

larval sense organ & antennal segment

(Tearle and Nusslein-Volhard, 1987)

larval sense organ & maxillary segment

(Tearle and Nusslein-Volhard, 1987)

midline glial cell

(Hummel et al., 1999)

motor neuron

(Hummel et al., 1999)

presumptive embryonic/larval central nervous system

(Hummel et al., 1999)

presumptive embryonic/larval peripheral nervous system

(Hummel et al., 1999)

sensory neuron

(Hummel et al., 1999)

symmetrical commissure

(Hummel et al., 1999)

ventral denticle belt

(Tearle and Nusslein-Volhard, 1987)

Detailed Description

Statement

Reference

Segmental commissures do not become separated into anterior and posterior axon bundles and appear fused. Mutant embryos show a clear fusion of commissures and frequent disruption of longitudinal connectives. Midline glial cells are either reduce in number or fail to properly migrate in between anterior and posterior commissures. General embryonic morphology is relatively normal, though the PNS shows a slight reduction in sensory neurons and defects in the trajectories of motoneurons.

(Hummel et al., 1999)

Homozygous embryos have narrow denticle bands and the ventral arms of the head skeleton are fused. Anal pads, Keilin's organs, maxillary sense organs and antennal organs are reduced. Heterozygotes have an eye phenotype.

(Tearle and Nusslein-Volhard, 1987)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

S^unspecified has visible | dominant phenotype, suppressible by Tcas\S^UAS.Tag:HA/Scer\GAL4^GMR.PF

(Rousso et al., 2010)

Enhancer of

Statement

Reference

S^unspecified is an enhancer of visible phenotype of Psn⁹/Psn¹⁴³

(Mahoney et al., 2006)

S^unspecified/S[+] is an enhancer of visible phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

S^unspecified/S[+] is an enhancer of lethal phenotype of Raf¹²

(Therrien et al., 2000)

NOT Enhancer of

Statement

Reference

S^unspecified/S[+] is a non-enhancer of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

S^unspecified/S[+] is a suppressor of visible phenotype of Scer\GAL4^Bx-MS1096, Tcas\stet^{UAS.GFP,Tag:ER(KDEL)}

(Rousso et al., 2010)

NOT Suppressor of

Statement

Reference

S^unspecified/S[+] is a non-suppressor of visible phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Phenotype Manifest In

Suppressed by

Statement

Reference

S^unspecified has eye phenotype, suppressible by Tcas\S^UAS.Tag:HA/Scer\GAL4^GMR.PF

(Rousso et al., 2010)

Enhancer of

Statement

Reference

S^unspecified is an enhancer of eye phenotype of Psn⁹/Psn¹⁴³

(Mahoney et al., 2006)

S^unspecified/S[+] is an enhancer of eye phenotype of ksr::tor^{ΔNksr.hs.sev}

(Therrien et al., 2000)

S^unspecified is an enhancer of phenotype of sina^GMR.PN

(Neufeld et al., 1998)

NOT Enhancer of

Statement

Reference

S^unspecified/S[+] is a non-enhancer of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Suppressor of

Statement

Reference

S^unspecified/S[+] is a suppressor of wing vein | ectopic phenotype of Scer\GAL4^Bx-MS1096, Tcas\stet^{UAS.GFP,Tag:ER(KDEL)}

(Rousso et al., 2010)

S^unspecified/S[+] is a suppressor of egg chorion phenotype of Scer\GAL4^CY2, grk^UAS.cGa

(Ghiglione et al., 2002)

S^unspecified/S[+] is a suppressor of dorsal appendage phenotype of Scer\GAL4^CY2, grk^UAS.cGa

(Ghiglione et al., 2002)

NOT Suppressor of

Statement

Reference

S^unspecified/S[+] is a non-suppressor of eye phenotype of Ras85D^V12.sev

(Therrien et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The mild wing vein phenotype generated by expression of Scer\GAL4^Bx-MS1096>Tcas\stet^{Scer\UAS.T:Avic\GFP} is attenuated by S^unspecified/+.

Expression of Tcas\S^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PF suppresses the rough eye phenotype that results from S^unspecified/+ haploinsufficiency.

(Rousso et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: Dominant modifier of the sina^GMR.PN eye phenotype.

(Neufeld et al., 1998)

Comments

"ethyl methanesulfonate" was stated as tentative. "X ray" was stated as tentative.

(Neufeld et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

S^unspecified

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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