FB2024_03 , released June 25, 2024
Allele: Dmel\Abd-Bunspecified
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General Information
Symbol
Dmel\Abd-Bunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0086939
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

NB6-4a-to-NB6-4t neuroblast homeotic transformations occur in Abd-Bunspecified mutants.

Homozygous clones transform posterior abdominal segments into more anterior ones, but are normal in the analia. In the genitalia, patches of cuticle bearing trichomes and bristles are often seen. Occasionally bracted bristles or a claw are seen, indicating transformation to leg tissue. Using the Minute method, more extensive transformation of genitalia into leg are seen, including leg elements such as claws, tarsus and tibia. In one case, leg structures typical of mesothoracic leg (apical bristle) has been seen in the transformed genitalia. In females, the ectopic legs substitute for much of the vulva and part of the vaginal plates, with some vaginal teeth frequently remaining. In males, the legs substitute for the hypandrium, penis apparatus and part of the clasper. Occasionally transformation of genitalia into distal antennae (2nd and/or 3rd antennal segment and arista) are seen. The transformations into leg or antenna are cell autonomous.

Many germ cells are able to coalesce along with gonadal mesoderm to form a gonad; however, some germ cells are excluded from this gonad, presumably due to the reduction in number of somatic gonadal precursors (SGPs). These 'lost' germ cells remain in an area ventral and posterior to the gonad until after coalescence.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Scrunspecified, Antpunspecified, Ubxunspecified, abd-Aunspecified mutants are profoundly affected in their development with abnormal or twisted dorsal closure.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

3 mutants are isolated.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Abd-Bunspecified
Name Synonyms
Secondary FlyBase IDs
    References (4)