medulla | P-stage, with Scer\GAL4bsh.M.PT
medulla | P-stage, with Scer\GAL4GMR69B02
medulla | P-stage, with Scer\GAL4sens.F2
medulla | P-stage, with Scer\GAL4sev.PM181
Expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4dome-PG14 results in mislocalisation of hemocyte precursors from the medullary zone into the cortical zone of the lymph gland, and differentiation of hemocyte precursors into plasmatocytes is observed.
Expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4Antp-10 causes a significant reduction in the number of cells of the posterior signalling center of the lymph gland. There is a reduction in the pool of hemocyte precursors, and the overall size of the lymph gland is reduced during third instar.
Expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4lz-gal4 results in a significant reduction in the number of crystal cells.
Ectopic expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC, under the control of Scer\GAL4vg.PM generates ectopic wing margin bristles.
Expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC in the retina behind the furrow using Scer\GAL4GMR.PF results in the projection of ventral R axons into the dorsal lamina.
Photoreceptor apoptosis at the periphery of developing eyes at 42 hours after puparium formation is almost completely eliminated in fz2ECD.GPI.Scer\UAS.T:Hsap\MYC; Scer\GAL4GMR.PF animals.
Expression of fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.G32 results in a phenotype similar to that produced by overexpression of sgg; the number of 1o, 2o and 3o denticles is unaffected, but the number of 4o denticles is severely reduced in the dorsal epidermis of the embryo (in wild-type embryos each parasegment contains 4 types of cells in the dorsal epidermis; the 1o, 2o and 3o cells in the anterior half of the parasegment and the 4o cells in the posterior half of the parasegment).
When driven by Scer\GAL4C96, almost all flies exhibit wings with anterior terminal nicking.
Embryos expressing fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.G32 show partially penetrant defects in the NB4-2 -> GMC-1 -> RP2/sib lineage and show defects in row 6 neuroblast formation. Temperature shift experiments in which fz2ECD.GPI.Scer\UAS.T:Hsap\MYC is expressed under the control of Scer\GAL4hs.PB at different times during embryogenesis indicate that the highest penetrance of RP2/sib lineage defects in these embryos occurs when fz2ECD.GPI.Scer\UAS.T:Hsap\MYC is expressed during midstage 8.
Flies expressing fz2ECD.GPI.Scer\UAS.T:Hsap\MYC in the wing pouch under the control of Scer\GAL4unspecified have severe notching of the wings.
Scer\GAL4unspecified-mediated expression results in loss of the wing margin.
Scer\GAL4bbg-C96/fz2ECD.GPI.UAS.Tag:MYC is an enhancer of visible phenotype of Scer\GAL4bbg-C96, mamN.UAS
Scer\GAL4da.G32, fz2ECD.GPI.UAS.Tag:MYC has larval RP2 motor neuron phenotype, enhanceable by wg[+]/wgunspecified
Scer\GAL4GMR.PF/fz2ECD.GPI.UAS.Tag:MYC is a suppressor of interommatidial bristle | cell autonomous phenotype of wgsev.PC
Scer\GAL4GMR.PF/fz2ECD.GPI.UAS.Tag:MYC is a non-suppressor of eye phenotype of Scer\GAL4GMR.PF, dshUAS.cAa
Scer\GAL4GMR.PF/fz2ECD.GPI.UAS.Tag:MYC is a non-suppressor of interommatidial bristle phenotype of Scer\GAL4GMR.PF, dshUAS.cAa
Enhances the wing nicking phenotype seen in mamN.Scer\UAS, Scer\GAL4C96 flies producing a wide range of phenotypes, including severe loss of blade material.
The penetrance of the phenotype seen in embryos expressing fz2ECD.GPI.Scer\UAS.T:Hsap\MYC under the control of Scer\GAL4da.G32 is enhanced if the embryos are also heterozygous for wgunspecified.
Carried in a plasmid and transfected into S2 cells to study the effects of the expressed membrane-bound fz2 on wg internalization.