FlyBase Allele Report: Dmel\dpp[EP2232]

General Information

Symbol

Dmel\dpp^EP2232

Species

D. melanogaster

Name

FlyBase ID

FBal0089340

Feature type

allele

Associated gene

Dmel\dpp

Associated Insertion(s)

P{EP}dpp^EP2232

Carried in Construct

Also Known As

EP(2)2232

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Rorth et al., 1998)

Progenitor genotype

Associated Insertion(s)

P{EP}dpp^EP2232

Cytology

Description

Inserted 400bp upstream from the start of the dpp first exon.

(McGovern et al., 2003)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:2,450,829..2,450,829 [+]

(Schulz et al., 2004, McGovern et al., 2003, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Rorth et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased occurrence of cell division | spermatogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Schulz et al., 2004)

lethal, with Scer\GAL4^en-e16E

(Tseng and Hariharan, 2002)

lethal, with Scer\GAL4^hs.2sev

(Tseng and Hariharan, 2002)

lethal, with Scer\GAL4^sca-4512

(McGovern et al., 2003)

visible, with Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

visible | dominant, with Scer\GAL4^bi-omb-Gal4

(Rorth et al., 1998)

Phenotype Manifest In

eye, with Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

larval longitudinal connective, with Scer\GAL4^sca-4512

(McGovern et al., 2003)

larval ventral nerve cord commissure, with Scer\GAL4^sca-4512

(McGovern et al., 2003)

spermatogonium, with Scer\GAL4^{VP16.nanos.UTR}

(Schulz et al., 2004)

wing, with Scer\GAL4^bi-omb-Gal4

(Rorth et al., 1998)

wing vein, with Scer\GAL4^bi-omb-Gal4

(Rorth et al., 1998)

Detailed Description

Statement

Reference

Expression of dpp^EP2232 under the control of Scer\GAL4^{nos.UTR.T:Hsim\VP16} (the animals are initially raised at 18^oC and are then shifted to 29^oC after 7 days) causes spermatogonia to continue mitotic proliferation at the expense of differentiation. This defect is seen in at least 50% of testes examined. Most of the early germ cells are clustered into cysts and are surrounded by somatic cyst cells.

(Schulz et al., 2004)

ventral nerve cord commissures in stage 17 dpp^EP2232; Scer\GAL4^sca-4512 embryos are fused and the longitudinal connectives are reduced in thickness.

(McGovern et al., 2003)

Expression of dpp^EP2232 under the control of Scer\GAL4^ey.PH results in eyes that are strongly reduced in size.

(Tseng and Hariharan, 2002)

Overexpression of dpp^EP2232 under the control of Scer\GAL4^bi-omb-Gal4 results in defects in wing growth and wing vein pattern.

(Rorth et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Scer\GAL4^ey.PH, dpp^EP2232 has visible phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Enhancer of

Statement

Reference

dpp^EP2232/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^ey.PH, dpp^EP2232 has eye phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Enhancer of

Statement

Reference

dpp^EP2232/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

Other

Statement

Reference

Scer\GAL4^pnr-MD237, dpp^EP2232, pnr^MD237/pnr[+] has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, dpp^EP2232, pnr^MD237 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

pnr^MD237/+ adults expressing dpp^EP2232 under the control of Scer\GAL4^pnr-MD237 have a strong thoracic cleft and a reduced scutellum.

(Pena-Rangel et al., 2002)

Co-expression of CycE^Scer\UAS.cLa does not suppress the small eye phenotype caused by expression of dpp^EP2232 under the control of Scer\GAL4^ey.PH.

(Tseng and Hariharan, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

7144

Df(2L)BSC37, dpp^EP2232/CyO

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dpp^EP2232

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

Open Close