FB2024_03 , released June 25, 2024
Allele: Dmel\tinUAS.cRa
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General Information
Symbol
Dmel\tinUAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Ranganayakulu
FlyBase ID
FBal0092487
Feature type
allele
Associated gene
Dmel\tin
Associated Insertion(s)
Carried in Construct
P{UAS-tin.R}
Also Known As
UAS-tin
Key Links
Transgenic product class
cDNA
(Ranganayakulu et al., 1998)
wild_type
(Ranganayakulu et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ranganayakulu et al., 1998)
wild_type
(Ranganayakulu et al., 1998)
Mutagen
in vitro construct
(Ranganayakulu et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-tin.R}
Cytology
Description

A tin cDNA is expressed under the control of UASt regulatory sequences.

(Ranganayakulu et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
tin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The number of gl-positive corpora cardiaca precursor cells is normal in stage 12 embryos expressing tinScer\UAS.cRa under the control of Scer\GAL4twi.2PE.

      (Park et al., 2011)

      Expression of tinScer\UAS.cRa in the mesoderm of embryos, driven by both Scer\GAL4how-24B and Scer\GAL4twi.PG, does not cause significant over-proliferation of cardioblasts or pericardial nephrocytes. There is also no detectable inhibition of lymph gland progenitor development.

      (Han and Olson, 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      tinUAS.cRa/Scer\GAL4how-24B is a non-suppressor of adult heart phenotype of pnrVX6

      (Qian and Bodmer, 2009)

      tinUAS.cRa/Scer\GAL4Mef2.PR is a non-suppressor of adult heart phenotype of pnrVX6

      (Qian and Bodmer, 2009)

      tinUAS.cRa, Scer\GAL4twi.PG, Scer\GAL4how-24B is a non-suppressor of adult heart phenotype of pnrVX6

      (Qian and Bodmer, 2009)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The number of gl-positive corpora cardiaca precursor cells is greatly expanded in stage 12 embryos co-expressing tinScer\UAS.cRa and daScer\UAS.cGa under the control of Scer\GAL4twi.2PE.

      (Park et al., 2011)

      The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnrVX6/+ adults is not rescued by expression of tinScer\UAS.cRa under the control of either Scer\GAL4how-24B or Scer\GAL4Mef2.PR.

      The increase in heart arrest/fibrillation upon electrical pacing that is seen in pnrVX6/+ adults is not rescued by expression of tinScer\UAS.cRa under the simultaneous control of both Scer\GAL4twi.PG and Scer\GAL4how-24B. The cardiac arrhythmias seen in pnrVX6/+ adults are also not rescued in these animals.

      (Qian and Bodmer, 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      tinUAS.cRa, Scer\GAL4twi.PB, Scer\GAL4Mef2.PR rescues tinEC40

      (Ranganayakulu et al., 1998)
      Comments

      Rescues visceral and cardiac mesoderm phenotype of tinEC40, when expression is driven by Scer\GAL4twi.PB and Scer\GAL4Mef2.PR.

      (Ranganayakulu et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      tinScer\UAS.cRa
      tinUAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Ranganayakulu
      (Ranganayakulu et al., 1998)
      Secondary FlyBase IDs
        References (11)