FlyBase Allele Report: Dmel\fz2[UAS.cZa]

General Information

Symbol

Dmel\fz2^UAS.cZa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Zhang

FlyBase ID

FBal0092981

Feature type

allele

Associated gene

Dmel\fz2

Associated Insertion(s)

Carried in Construct

P{UAS-fz2.Z}

Also Known As

UAS-Frizzled2, UAS-Dfz2

Key Links

Transgenic product class

cDNA

(Zhang and Carthew, 1998)

wild_type

(Zhang and Carthew, 1998)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Zhang and Carthew, 1998)

wild_type

(Zhang and Carthew, 1998)

Mutagen

in vitro construct

(Zhang and Carthew, 1998)

Progenitor genotype

Carried in construct

P{UAS-fz2.Z}

Cytology

Description

cDNA sequence which includes the entire open reading frame is expressed from UASt regulatory sequences.

(Zhang and Carthew, 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

fz2

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^69B

(Zhang and Carthew, 1998)

Phenotype Manifest In

denticle row 1, with Scer\GAL4^en-e16E

(Lecourtois et al., 2001)

macrochaeta | ectopic, with Scer\GAL4^69B

(Zhang and Carthew, 1998)

wing, with Scer\GAL4^69B

(Zhang and Carthew, 1998)

wing & macrochaeta, with Scer\GAL4^69B

(Zhang and Carthew, 1998)

wing margin bristle | ectopic, with Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

wing sensillum | ectopic, with Scer\GAL4^69B

(Zhang and Carthew, 1998)

Detailed Description

Statement

Reference

fz2^Scer\UAS.cZa, Scer\GAL4^en-e16E embryos lose type 1 denticles. This is seen in all embryos, although at times, one or two segments remain unaffected.

(Lecourtois et al., 2001)

Overexpression of fz2^Scer\UAS.cZa does not affect the wild-type denticle pattern.

(Moline et al., 2000)

When expression is driven by Scer\GAL4^69B, supernumerary stout mechanosensory bristles appear one or two cell diameters from the normal row, supernumerary slender mechanosensory bristles and chemosensory bristles appear one or more rows from the wing margin and supernumerary posterior hairs appear in the interior of the posterior wing. Ectopic bristles are more numerous near the margin, and the type of ectopic bristle formed correlates with its distance from the margin; those close to the margin are of the stout mechanosensory type, whereas those further distant are of the slender mechanosensory or chemosensory types. When expression is driven by Scer\GAL4^hs.2sev, ommatidia are normally oriented and otherwise unaffected. Suppresses wing margin loss phenotype of fz2^Scer\UAS.N. Ectopic bristle induction suppressed by fz2^Scer\UAS.N.

(Zhang and Carthew, 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fz2^UAS.cZa/Scer\GAL4^69B is a suppressor of visible phenotype of Scer\GAL4^69B, fz^UAS.N

(Zhang and Carthew, 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^e22c, fz2^UAS.cZa has embryonic/larval epidermis phenotype, enhanceable by wg^PE2.UAS/Scer\GAL4^e22c

(Moline et al., 2000)

Scer\GAL4^e22c, fz2^UAS.cZa has ventral denticle belt phenotype, enhanceable by wg^PE2.UAS/Scer\GAL4^e22c

(Moline et al., 2000)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-enhanceable by Cow^UAS.cCa, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-enhanceable by Cow^RNAi.UAS, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-enhanceable by Cow^RNAi.UAS.1, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Suppressed by

Statement

Reference

Scer\GAL4^69B, fz2^UAS.cZa has wing sensillum | ectopic phenotype, suppressible by wg^l-17

(Zhang and Carthew, 1998)

Scer\GAL4^69B, fz2^UAS.cZa has wing sensillum | ectopic phenotype, suppressible by Scer\GAL4^69B/fz^UAS.N

(Zhang and Carthew, 1998)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-suppressible by Cow^UAS.cCa, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-suppressible by Cow^RNAi.UAS, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Scer\GAL4^Bx-MS1096, fz2^UAS.cZa has wing margin bristle phenotype, non-suppressible by Cow^RNAi.UAS.1, Scer\GAL4^Bx-MS1096

(Chang and Sun, 2014)

Enhancer of

Statement

Reference

fz2^UAS.cZa/Scer\GAL4^e22c is an enhancer of embryonic/larval epidermis phenotype of Scer\GAL4^e22c, wg^PE2.UAS

(Moline et al., 2000)

fz2^UAS.cZa/Scer\GAL4^e22c is an enhancer of ventral denticle belt phenotype of Scer\GAL4^e22c, wg^PE2.UAS

(Moline et al., 2000)

fz2^UAS.cZa, dally^hs.PJ, Scer\GAL4^e22c is an enhancer of phenotype of wg^PE2

(Moline et al., 2000)

NOT Enhancer of

Statement

Reference

fz2^UAS.cZa/Scer\GAL4^e22c is a non-enhancer of phenotype of wg^l-17

(Moline et al., 2000)

Suppressor of

Statement

Reference

Scer\GAL4^prd.RG1/fz2^UAS.cZa is a suppressor of phenotype of wg^PE2

(Moline et al., 2000)

fz2^UAS.cZa/Scer\GAL4^e22c is a suppressor of phenotype of wg^PE2

(Moline et al., 2000)

NOT Suppressor of

Statement

Reference

fz2^UAS.cZa/Scer\GAL4^e22c is a non-suppressor of phenotype of wg^l-17

(Moline et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

Over expression of fz2^Scer\UAS.cZa and wg^PE2.Scer\UAS driven by Scer\GAL4^e22c produces uniformly naked cuticle.

(Moline et al., 2000)

The supernumerary wing bristle phenotypes can be suppressed by wg^l-17. Suppresses wing margin loss phenotype of fz^Scer\UAS.N. Ectopic bristle induction suppressed by fz^Scer\UAS.N.

(Zhang and Carthew, 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

fz2^UAS.cZa is rescued by fz2^UAS.N/Scer\GAL4^69B

(Zhang and Carthew, 1998)

Rescues

fz2^UAS.cZa/Scer\GAL4^69B rescues fz2^UAS.N

(Zhang and Carthew, 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

fz2^Scer\UAS.cZa

fz2^UAS.cZa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Zhang

(Zhang and Carthew, 1998)

Secondary FlyBase IDs

References (8)

Report Sections

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