FlyBase Allele Report: Dmel\dve[A.UAS]

General Information

Symbol

Dmel\dve^A.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0093031

Feature type

allele

Associated gene

Dmel\dve

Associated Insertion(s)

Carried in Construct

P{UAS-dve.A}

Also Known As

UAS-dveA-9B2

Key Links

Transgenic product class

wild_type

(Minami et al., 2012)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Minami et al., 2012)

Mutagen

in vitro construct

(Nakagoshi et al., 1998)

Progenitor genotype

Carried in construct

P{UAS-dve.A}

Cytology

Description

UASt regulatory sequences drive expression of the dve-A isoform.

(Minami et al., 2012)

UASt regulatory sequences drive expression of a 4.5kb EcoRI fragment of dve cDNA.

(Nakagoshi et al., 1998)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dve

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^vg.PM

(Nakagoshi et al., 2002)

Phenotype Manifest In

copper cell, with Scer\GAL4^48Y

(Nakagawa et al., 2011)

copper cell, with Scer\GAL4^hs.PB

(Nakagoshi et al., 1998)

copper cell, with Scer\GAL4^NP3012

(Nakagawa et al., 2011)

midgut, with Scer\GAL4^48Y

(Nakagawa et al., 2011)

midgut, with Scer\GAL4^NP3012

(Nakagawa et al., 2011)

wing, with Scer\GAL4^vg.PM

(Nakagoshi et al., 2002)

Detailed Description

Statement

Reference

Expression of dve^Scer\UAS.cNa in all cells in the midgut under the control of Scer\GAL4^48Y results on impaired gut functions, with a reduction in acid secretion and a slight reduction copper absorption.

Expression of dve^Scer\UAS.cNa in all cells in the midgut under the control of Scer\GAL4^NP3012 results in impaired gut functions, with a reduction in acid secretion and a slight reduction copper absorption.

Expression of dve^Scer\UAS.cNa under the control of Scer\GAL4^NP3157 or Scer\GAL4^NP3207 does not affect gut function.

(Nakagawa et al., 2011)

Expression of dve^Scer\UAS.cNa under the control of Scer\GAL4^vg.PM results in a variable wing phenotype, with some adults only having rudimentary wings and others having notched wings.

(Nakagoshi et al., 2002)

Expression of dve^Scer\UAS.cNa under the control of Scer\GAL4^hs.PB using heat shock at stage 17 results in abnormal morphology of copper cells; the typical banana shape of the cells is often lost, with the cells becoming circular.

(Nakagoshi et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

dve^A.UAS/Scer\GAL4^dve.13 rescues dve^E181/dve^E144

(Minami et al., 2012)

Comments

The loss of secondary cells in the accessory glands of dve^E181/dve^E144 males is rescued by expression of dve^A.Scer\UAS under the control of Scer\GAL4^dve.13.

(Minami et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

dve^A.Scer\UAS

dve^A.UAS

dve^Scer\UAS.cNa

dve^UAS.cNa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Nakagoshi

(Nakagoshi et al., 1998)

Secondary FlyBase IDs

References (6)

Report Sections

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