FB2024_03 , released June 25, 2024
Allele: Dmel\dshΔDIX.UAS
Open Close
General Information
Symbol
Dmel\dshΔDIX.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0093067
Feature type
allele
Associated gene
Dmel\dsh
Associated Insertion(s)
Carried in Construct
P{UAS-dsh.ΔDIX}
Key Links
Transgenic product class
inframe_deletion
(Axelrod et al., 1998)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Axelrod et al., 1998)
Mutagen
in vitro construct
(Axelrod et al., 1998)
Progenitor genotype
Carried in construct
P{UAS-dsh.ΔDIX}
Cytology
Description

dsh amino acids 1 to 41 and 152 to 623 are expressed under the control of UASt regulatory sequences.

(Axelrod et al., 1998)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsh
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Animals expressing dshΔDIX.Scer\UAS under the control of Scer\GAL4arm.PS display a loss of denticles. The arrangement of cells and cell morphology are greatly disrupted.

      (Kaplan and Tolwinski, 2010)

      Expression of dshΔDIX.Scer\UAS under the control of Scer\GAL4hs.PB produces a weak phenotype in the wing.

      (Axelrod et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Suppressor of
      Statement
      Reference

      dshΔDIX.UAS/Scer\GAL469B is a suppressor of amnioserosa phenotype of hep1

      (Kaltschmidt et al., 2002)

      dshΔDIX.UAS/Scer\GAL469B is a suppressor of embryonic dorsal epidermis phenotype of hep1

      (Kaltschmidt et al., 2002)

      dshΔDIX.UAS/Scer\GAL469B is a suppressor of embryonic leading edge cell & actin filament phenotype of hep1

      (Kaltschmidt et al., 2002)

      dshΔDIX.UAS/Scer\GAL469B is a suppressor of embryonic/first instar larval cuticle | dorsal phenotype of hep1

      (Kaltschmidt et al., 2002)
      NOT Suppressor of
      Statement
      Reference

      dshΔDIX.UAS/Scer\GAL4da.G32 is a non-suppressor of denticle | ectopic phenotype of wgl-17

      (Morel and Arias, 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      dshΔDIX.Scer\UAS; Scer\GAL4da.G32 does not suppress the transformation of naked ventral cuticle into denticles in cuticles from wgl-17 homozygous embryos. The resulting cuticles are even shorter and more puckered than those from wgl-17 homozygous embryos, have an enlarged dorsal hole.

      (Morel and Arias, 2004)

      The dorsal hole phenotype, loss of leading edge actin cable, and loss of adhesion between the amnioserosa and dorsal epidermis of hep1 mutant embryos are all partially suppressed by Scer\GAL469B with dshΔDIX.Scer\UAS.

      (Kaltschmidt et al., 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dshΔDIX.Scer\UAS
      dshΔDIX.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (4)