FB2024_03 , released June 25, 2024
Allele: Dmel\fl(1)3546
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General Information
Symbol
Dmel\fl(1)3546
Species
D. melanogaster
Name
FlyBase ID
FBal0094542
Feature type
allele
Associated gene
fl(1)35
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Anand et al., 1998)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Females doubly heterozygous for fl(1)3546 and Sxlf1 or SxlfP7B0 show very poor viability; 3.5% and 2.1% respectively. Lethality of fl(1)3546/Sxlf1 females can occur at embryonic or larval stages. The lethality can be partially rescued by Dp(1;3)sn13a1. The viability of fl(1)3546 in female double heterozygous combination with Sxlf9, SxlfLS, Sxlf7,M1 or SxlM1,f3 is reduced. Females doubly heterozygous for fl(1)3546 and either sc10-1 or sisA1 show reduced viability compared to single heterozygous females. Females doubly heterozygous for fl(1)3546 and Df(1)RA37 do not show reduced viability compared to single heterozygous females. Does not interact with da1. Does not interact with fl(2)d1 or fl(2)d2.

      (Anand et al., 1998)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The proximity of the genetic locations of fl(1)3535 and fl(1)3546 and the similarities in phenotype (male viability and female viability, and comparable level of interaction with Sxl alleles) suggest that they are allelic.

      (Anand et al., 1998)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      fl(1)3546
      fl-46
      (Anand et al., 1998)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)