FlyBase Allele Report: Dmel\trol[G0271]

General Information

Symbol

Dmel\trol^G0271

Species

D. melanogaster

Name

FlyBase ID

FBal0098134

Feature type

allele

Associated gene

Dmel\trol

Associated Insertion(s)

P{lacW}trol^G0271

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schäfer et al., 1999.6.15)

Progenitor genotype

Associated Insertion(s)

P{lacW}trol^G0271

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:2,518,136..2,518,143

(Bonche et al., 2022, Pastor-Pareja and Xu, 2011, Peter et al., 2002, Voigt et al., 2002, Schäfer et al., 1999.6.15)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

AJ300055

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval brain

(Voigt et al., 2002)

embryonic/larval brain | third instar larval stage

(Skeath et al., 2017)

embryonic/larval optic lobe

(Voigt et al., 2002)

haltere disc

(Voigt et al., 2002)

larval ventral nerve cord | third instar larval stage

(Skeath et al., 2017)

wing disc

(Voigt et al., 2002)

Detailed Description

Statement

Reference

trol^G0271 mutant third instar larvae display morphological defects in the brain: a neural invasion phenotype (neural cells from the brain invade adjacent peripheral structures) as well as protrusions of varied size from the brain and nerve cord.

(Skeath et al., 2017)

trol^G0271 mutants exhibit more compact looking imaginal discs, with sections showing elongation of cells in the apico-basal axis. in addition, the central nervous system shows signs of hyper-constriction, with vesicles of tissue herniating from the ventral nerve cord.

(Pastor-Pareja and Xu, 2011)

Lethality occurs from the third larval instar through to the pupal stage.

(Peter et al., 2002)

Hemizygous larvae develop smaller optic lobes than controls, while other parts of the brain show overgrowth defects. The thoracic ganglion region is disrupted.

The wing discs of hemizygous larvae are convoluted and reduced in size compared to controls. The wing pouch is rotated 90[o] relative to the dorsoventral axis and the dorsal body wall region is heavily reduced in size. The haltere disc is heavily convoluted in the mutant larvae.

Hemizygous larvae take at least 1 day longer to reach third larval instar compared to controls, and eventually die as third instar larvae.

(Voigt et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

trol^G0271/trol^G0271 is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of AdamTS-A^UAS.RB, Scer\GAL4^repo

(Skeath et al., 2017)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

trol^G0271/trol^G0271 is a non-suppressor of larval ventral nerve cord | third instar larval stage phenotype of AdamTS-A^UAS.RB, Scer\GAL4^repo

(Skeath et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The abnormal elongation of ventral nerve cord observed in third instar larvae expressing AdamTS-A^UAS.RB under the control of Scer\GAL4^repo is not prevented by homozygosity of trol^G0271.

(Skeath et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

trol¹⁵

(Voigt et al., 2002)

trol¹³

(Voigt et al., 2002)

Comments

Images (0)