sfl9B4 heterozygotes exhibit increased median survival time compared to controls when infected with group B Streptococcus (both wild-type and GAG-binding impaired mutants) and lower colony counts after infection.
In response to nerve stimulation, sfl9B4/sfl03844 mutants exhibit a significantly increased EJP compared with wild-type or heterozygous control larvae (20-25% increase). Spontaneous release events (mEJPs) are substantially reduced compared with heterozygous or wild-type controls, suggesting that loss of Heparan Sulfate biosynthesis affects the spontaneous vesicle release probability in the motoneuron. Post-synaptic mEJP amplitudes are modestly increased in sfl9B4/sfl03844 mutants relative to heterozygous or wild-type controls.
sfl9B4/sfl03844 mutant larval exhibit locomotion defects, with a significantly reduced number of peristaltic contractions per minute.
sfl9B4 mutants exhibit a loss of tracheoblasts.
sfl9B4 is a suppressor of flight muscle cell | adult stage phenotype of parkΔ21/park1