FB2024_03 , released June 25, 2024
Allele: Dmel\sfl9B4
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General Information
Symbol
Dmel\sfl9B4
Species
D. melanogaster
Name
FlyBase ID
FBal0098659
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
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    Phenotypic Data
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    sfl9B4 heterozygotes exhibit increased median survival time compared to controls when infected with group B Streptococcus (both wild-type and GAG-binding impaired mutants) and lower colony counts after infection.

    In response to nerve stimulation, sfl9B4/sfl03844 mutants exhibit a significantly increased EJP compared with wild-type or heterozygous control larvae (20-25% increase). Spontaneous release events (mEJPs) are substantially reduced compared with heterozygous or wild-type controls, suggesting that loss of Heparan Sulfate biosynthesis affects the spontaneous vesicle release probability in the motoneuron. Post-synaptic mEJP amplitudes are modestly increased in sfl9B4/sfl03844 mutants relative to heterozygous or wild-type controls.

    sfl9B4/sfl03844 mutant larval exhibit locomotion defects, with a significantly reduced number of peristaltic contractions per minute.

    sfl9B4 mutants exhibit a loss of tracheoblasts.

    neur expressing sensory organ mother cells are missing in sfl03844/sfl9B4 wing discs.

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      References (12)