FB2024_03 , released June 25, 2024
Allele: Dmel\MycG0354
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General Information
Symbol
Dmel\MycG0354
Species
D. melanogaster
Name
FlyBase ID
FBal0100308
Feature type
allele
Associated gene
Dmel\Myc
Associated Insertion(s)
P{lacW}MycG0354
Carried in Construct
Also Known As
dmG0354, dmyc-lacZ
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Schäfer et al., 1999.8.12)
Progenitor genotype
Associated Insertion(s)
P{lacW}MycG0354
Cytology
Description

P{lacW} insertion in the proximal promoter region of dm.

(Neto-Silva et al., 2010)
Allele components
Component
Use(s)
Inserted element
P{lacW}
Encoded product / tool
lacZ
Tagged with
Tag:NLS(P)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AJ300088
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      MycG0354/+ third instar larvae do not show any changes in the number of mitotic cells in the wing disc.

      (Lee et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Myc[+]/MycG0354 is a suppressor of abnormal cell cycle | third instar larval stage phenotype of hay[+]/haync2rv1, hfpEP3058

      (Lee et al., 2015)

      Myc[+]/MycG0354 is a suppressor of increased occurrence of cell division | third instar larval stage phenotype of hfpEP3058

      (Lee et al., 2015)
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      MycG0354 is a suppressor of wing disc | third instar larval stage phenotype of hay[+]/haync2rv1, hfpEP3058

      (Lee et al., 2015)

      Myc[+]/MycG0354 is a suppressor of wing disc | third instar larval stage phenotype of hfpEP3058

      (Lee et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      haync2rv1/+;MycG0354/+ double heterozygotes do not show significant changes in the number of mitotic cells in the third instar larval wing disc compared to controls.

      haync2/+;MycG0354/+ double heterozygotes do not show any changes in the number of mitotic cells in the third instar larval wing discs compared to wild-type controls.

      The number of mitotic cells in the wing disc of hfpEP3058/hfpEP3058;haync2/+ third instar larvae is not changed by combination with MycG0354 in heterozygous state.

      The increased number of mitotic cells characteristic for hfpEP3058/hfpEP3058;haync2rv1/+ third instar larvae can be rescued by combination with MycG0354 in heterozygous state.

      (Lee et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      P{lacW} not verified as causing the lethality.

      (Schäfer et al., 1999.8.12)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      MycG0354
      dmG0354
      (Lee et al., 2015, Neto-Silva et al., 2010)
      l(1)G0354
      (Peter et al., 2002)
      l(1)G0354G0354
      Name Synonyms
      Secondary FlyBase IDs
        References (4)