FB2024_03 , released June 25, 2024
Allele: Dmel\spir2F
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General Information
Symbol
Dmel\spir2F
Species
D. melanogaster
Name
FlyBase ID
FBal0102386
Feature type
allele
Associated gene
Dmel\spir
Associated Insertion(s)
Carried in Construct
Also Known As
spire2F
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: Q246term.

    (Wellington et al., 1999)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:20,334,150..20,334,150 [+]
    Nucleotide change:

    C20334150T

    Amino acid change:

    Q246term | spir-PA; Q246term | spir-PB; Q246term | spir-PD; Q246term | spir-PE; Q246term | spir-PF; Q246term | spir-PG; Q246term | spir-PH; Q246term | spir-PI; Q246term | spir-PJ

    Reported amino acid change:

    Q246term

    Comment:

    Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

    (Wellington et al., 1999)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Other
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        spir[+]/spir2F is a suppressor | partially of embryonic head phenotype of miraαTub67C.mGFP6

        (Chang et al., 2011)
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The bicaudal phenotype of embryos derived from miraαTub67C.T:Avic\GFP-m6/+ females is suppressed if the females are also heterozygous for spir2F.

        (Chang et al., 2011)

        Stage 7 oocytes from capu1, spir2F mothers undergo premature ooplasmic streaming.

        (Rosales-Nieves et al., 2006)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        spir2F/spir1 is rescued by spirUAS.ORF.Tag:HA/Scer\GAL4smid-C161

        (Stürner et al., 2022)
        Comments

        The loss of the actin mesh in the cytoplasm of stage 9 spir1/spir2F oocytes is rescued by expression of spirRD.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16. Ectopic actin mesh-like structures are also induced in the nurse cells in these animals.

        (Dahlgaard et al., 2007)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        spir2F
        (Stürner et al., 2022, Ferreira et al., 2014)
        spire 2F
        (Stürner et al., 2022)
        spire2F
        (Wood et al., 2024, Chang et al., 2011, Dahlgaard et al., 2007)
        Name Synonyms
        Secondary FlyBase IDs
          References (7)