FB2024_03 , released June 25, 2024
Allele: Dmel\klarUAS.Tag:MYC
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General Information
Symbol
Dmel\klarUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0102660
Feature type
allele
Associated gene
Dmel\klar
Associated Insertion(s)
Carried in Construct
P{UAS-klar.M}
Key Links
Transgenic product class
cDNA
(Mosley-Bishop et al., 1999)
wild_type
(Mosley-Bishop et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Mosley-Bishop et al., 1999)
wild_type
(Mosley-Bishop et al., 1999)
Mutagen
in vitro construct
(Mosley-Bishop et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-klar.M}
Cytology
Description

UAS regulatory sequences drive expression of a klar cDNA tagged with Tag:MYC.

(Mosley-Bishop et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
klar
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of klarScer\UAS.T:Hsap\MYC under the control of Scer\GAL4fkh.PH increases the size of the salivary gland lumen in embryos, often resulting in a branched lumen.

      (Myat and Andrew, 2002)

      klarScer\UAS.T:Hsap\MYC when driven by Scer\GAL4elav-C155, can exhibit an eye phenotype. A rough eye phenotype is seen, in the retina facets are disorganised and far too few photoreceptors are seen. R-cell apical nuclear migration and cone cell migration are wild-type.

      (Mosley-Bishop et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The salivary gland defects of hkb2 embryos are partially rescued by expression of klarScer\UAS.T:Hsap\MYC under the control of Scer\GAL4wg.PM; the percentage of salivary glands with normal, elongated lumens is increased from 7% to 27%.

      (Myat and Andrew, 2002)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      klarScer\UAS.T:Hsap\MYC
      klarScer\UAS.cMa
      klarUAS.Tag:MYC
      klsScer\UAS.cMa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)