FlyBase Allele Report: Dmel\drl[Red2]

General Information

Symbol

Dmel\drl^Red2

Species

D. melanogaster

Name

FlyBase ID

FBal0102745

Feature type

allele

Associated gene

Dmel\drl

Associated Insertion(s)

P{etau-lacZ}drl^Red2

Carried in Construct

Key Links

Allele class

loss of function allele

Mutagen

P-element activity

Nature of the Allele

Allele class

loss of function allele

(Bonkowsky et al., 1999)

Mutagen

P-element activity

(Yoshikawa et al., 2003, Bonkowsky et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{etau-lacZ}drl^Red2

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{etau-lacZ}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:MT(btau)

microtubule protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

larval anterior commissure

(Bonkowsky et al., 1999)

lateral transverse muscle cell | embryonic stage 16

(Lahaye et al., 2012)

lateral transverse muscle cell | embryonic stage 16 (with Df(2L)ED1231)

(Lahaye et al., 2012)

lateral transverse muscle cell | embryonic stage 16 (with Df(2L)Exel6043)

(Lahaye et al., 2012)

lateral transverse muscle cell | third instar larval stage

(Lahaye et al., 2012)

Detailed Description

Statement

Reference

In 36% of the hemisegments of drl^Red2 stage 16 embryos, lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7. This phenotype is usually only seen in one the three muscles per hemisegment. This LTM overextension phenotype is seen in 16% of third instar larvae.

In 50%% of hemisegments in drl^Red2/Df(2L)Exel6043 the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7.

In 50%% of hemisegments in drl^Red2/Df(2L)ED1231 the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7.

The epidermal clusters of tendon cell precursors in stage 11/12 drl^Red2 mutant embryos are similar in size and location to wild type clusters.

(Lahaye et al., 2012)

Anterior commissure (AC) axons project normally and never enter the posterior commissure (PC) in heterozygous embryos. In homozygous embryos, 34% of segments have AC axons that project entirely through the PC, as well as axons that leave the AC and enter the PC near the midline.

(Bonkowsky et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

drl[+]/drl^Red2 is a non-enhancer of abnormal neuroanatomy | adult stage | dominant phenotype of tap^Gal4

(Yuan et al., 2016)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

drl^Red2 has lateral transverse muscle cell | embryonic stage 16 phenotype, non-enhanceable by Drl-2^E124

(Lahaye et al., 2012)

NOT suppressed by

Statement

Reference

drl^Red2 has lateral transverse muscle cell | embryonic stage 16 phenotype, non-suppressible by Wnt5⁴⁰⁰

(Lahaye et al., 2012)

Enhancer of

Statement

Reference

drl^Red2 is an enhancer of lateral transverse muscle cell | embryonic stage 16 phenotype of Wnt5⁴⁰⁰

(Lahaye et al., 2012)

NOT Enhancer of

Statement

Reference

drl[+]/drl^Red2 is a non-enhancer of adult mushroom body beta-lobe | adult stage phenotype of tap^Gal4

(Yuan et al., 2016)

Suppressor of

Statement

Reference

drl^Red2 is a suppressor of larval anterior commissure phenotype of Scer\GAL4^sim.PS, Wnt5^EY03178

(Yoshikawa et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

drl^Red2/+ or sli²/+ does not significantly enhance frequency of mushroom body beta lobe axon overgrowth defects in tap^Gal4/+ brains.

(Yuan et al., 2016)

In 36% of the hemisegments in drl^Red2 Wnt5⁴⁰⁰ double mutant embryos, the lateral transverse muscles (LTMs) bypass their normal attachment at the epidermis at muscle 12 and instead extend ventrally beyond muscle 13 and attach at a novel epidermal site located close to muscle fiber 7. This is similar to the number seen in drl^Red2 single mutants, but significantly more than is seen in Wnt5⁴⁰⁰ mutants.

Drl-2^E124 does not enhance the lateral transverse muscle attachment defects seen in drl^Red2 mutant stage 16 embryos.

(Lahaye et al., 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

drl^Red2 is rescued by drl^UAS.cCa/Scer\GAL4^Mef2.PR

(Lahaye et al., 2012)

Not rescued by

drl^Red2 is not rescued by drl^UAS.cCa/Scer\GAL4^sr-md710

(Lahaye et al., 2012)

Comments

Expression of drl^Scer\UAS.cCa under the control of Scer\GAL4^Mef2.PR rescues the lateral transverse muscle attachment defects seen in drl^Red2 mutant stage 16 embryos. No rescue is seen when drl^Scer\UAS.cCa is expressed under the control of Scer\GAL4^sr-md710.

(Lahaye et al., 2012)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

drl^Red2

(Zhu et al., 2019, Yuan et al., 2016, Lahaye et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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