FlyBase Allele Report: Dmel\disp[S037707]

General Information

Symbol

Dmel\disp^S037707

Species

D. melanogaster

Name

FlyBase ID

FBal0102761

Feature type

allele

Associated gene

Dmel\disp

Associated Insertion(s)

P{lacW}disp^S037707

Carried in Construct

Also Known As

disp³⁷⁷

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Gallet et al., 2003, Burke et al., 1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}disp^S037707

Cytology

Description

P{lacW} insertion within a opus element within an intron of disp, located at amino acid 812.

(Burke et al., 1999)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased size | larval stage

(Hatori and Kornberg, 2020)

lethal | embryonic stage | recessive | rescuable maternal effect

(Burke et al., 1999)

lethal | pupal stage | recessive

(Burke et al., 1999)

segment polarity phenotype | embryonic stage | recessive | rescuable maternal effect

(Burke et al., 1999)

Phenotype Manifest In

Detailed Description

Statement

Reference

In disp^S037707 larvae, the wing disc pouch is small, the wing disc cells show less abundant and shorter microvilli, as well as fewer extracellular vesicles.

(Hurbain et al., 2022)

First instar larvae in which disp^S037707 germline clones have been induced exhibit only type 4 cuticle cells.

(Gallet et al., 2006)

The ventral cuticles of disp^S037707 germ-line clone embryos lack naked cuticle, instead forming a lawn of small denticles different from row 5 type.

(Gallet et al., 2003)

Homozygotes lacking zygotic disp function survive until early pupal stages. Animals lacking both maternal and zygotic disp function die during embryogenesis with a strong segment-polarity phenotype; the embryos display a lawn of denticle belts and fail to secrete ventral cuticle. The embryos are rescued by a disp⁺ paternal chromosome. Homozygous clones in the wing can contribute to wild-type wing margin structures. Large clones in the posterior compartment cause a significant reduction in the distance between veins L3 and L4. The wing is reduced in size, but otherwise patterning remains normal.

(Burke et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

disp^S037707 has embryonic/first instar larval cuticle | germline clone phenotype, suppressible by Scer\GAL4^unspecified/hh^UAS.cIa

(Gallet et al., 2006)

Suppressor of

Statement

Reference

disp^S037707 is a suppressor | partially of denticle | germline clone | maternal effect phenotype of Scer\GAL4^en-e16E, hh^UAS.cIa

(Gallet et al., 2003)

NOT Suppressor of

Statement

Reference

disp^S037707 is a non-suppressor of wing disc | anterior phenotype of Scer\GAL4^en-e16E, hh^N.UAS.Tag:HA

(Burke et al., 1999)

disp^S037707 is a non-suppressor of wing disc phenotype of Scer\GAL4^en-e16E, hh^CD2.UAS, hh^ts2

(Burke et al., 1999)

Other

Statement

Reference

Scer\GAL4^unspecified, disp^S037707, hh^C85S.UAS.cGa has embryonic/first instar larval cuticle phenotype

(Gallet et al., 2006)

Scer\GAL4^en-e16E, disp^S037707, hh^N.UAS.cGa has denticle | germline clone | maternal effect phenotype

(Gallet et al., 2003)

Scer\GAL4^en-e16E, disp^S037707, hh^UAS.cIa has denticle | germline clone | maternal effect phenotype

(Gallet et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of hh^Scer\UAS.cIa, under the control of Scer\GAL4^unspecified in disp^S037707 mutant embryos rescues some type 1 cuticle, but no type 2 or type 1 cuticle is formed.

(Gallet et al., 2006)

Expression of hh^Scer\UAS.cIa with Scer\GAL4^en-e16E in disp^S037707 germ-line clone embryos doesn't rescue naked cuticle formation, but does increase denticle diversity in the ventral cuticle: row 3,4 and 5 type denticles are all present. Expression of hh^{N.Scer\UAS.cGa} with Scer\GAL4^en-e16E in disp^S037707 germ-line clone embryos doesn't rescue naked cuticle formation, but does increase denticle diversity in the ventral cuticle: row 3,4 and 5 type denticles are all present: denticles type 3 and 4 cover each segment, whereas type 5 denticles have almost totally disappeared.

(Gallet et al., 2003)

The overgrowth of the anterior compartment of the wing disc seen in larvae expressing hh^{N.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^en-e16E in a hh^ts2 background is still seen if the discs are also carrying disp^S037707. The ability of hh^{SF.Scer\UAS.T:Rnor\CD2} to rescue the growth defects of hh^ts2 wing imaginal discs when expressed under the control of Scer\GAL4^en-e16E is unaffected if the discs are also homozygous for disp^S037707.

(Burke et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

disp^S037707 is rescued by disp^αTub84B.PB

(Burke et al., 1999)

Partially rescued by

disp^S037707 is partially rescued by Scer\GAL4^en-e16E/disp^UAS.Tag:HA

(Burke et al., 1999)

Comments

disp^{Scer\UAS.T:Ivir\HA1} rescues disp^S037707 animals to adulthood when expressed under the control of Scer\GAL4^en-e16E. The rescued flies have normal patterning in the wing, leg, notum and abdomen and give rise to viable offspring, but have a dramatic reduction in eye size.

(Burke et al., 1999)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

53711

P{hsFLP}12, y¹ w^*; P{neoFRT}82B P{lacW}disp^S037707/TM6B, Tb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

disp³⁷⁷

(D'Angelo et al., 2015, Gallet et al., 2006)

disp^377w+

(Gallet et al., 2003)

disp^P

(Chang et al., 2013)

disp^S037707

(Hurbain et al., 2022, Spannl et al., 2020, Palm et al., 2013, Khaliullina et al., 2009)

disp^SO37707

(D'Angelo et al., 2015)

disp^l(3)S037707

(Amanai and Jiang, 2001)

l(3)S037707

(Burke et al., 1999)

Name Synonyms

Secondary FlyBase IDs

References (12)

Report Sections

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