FlyBase Allele Report: Dmel\H[P8]

General Information

Symbol

Dmel\H^P8

Species

D. melanogaster

Name

FlyBase ID

FBal0104136

Feature type

allele

Associated gene

Dmel\H

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Nagel et al., 2000)

Mutagen

P-element activity

(Maier et al., 1999)

Progenitor genotype

H^D179

(Maier et al., 1999)

Cytology

Description

Imprecise excision of P{lacW}H^D179 creates a deletion from within the P insertion upstream of the translation initiation site, to codon 429, in the open reading frame.

(Maier et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with H⁹⁹)

(Nagel et al., 2000)

visible | dominant

(Nagel et al., 2016, Maier et al., 2002)

Phenotype Manifest In

eo neuron (with H¹)

(Nagel et al., 2000)

macrochaeta

(Maier et al., 2002)

thecogen cell (with H¹)

(Nagel et al., 2000)

tormogen cell | ectopic (with H⁹⁹)

(Nagel et al., 2000)

trichogen cell (with H⁹⁹)

(Nagel et al., 2000)

wing vein | adult stage

(Nagel et al., 2016)

Detailed Description

Statement

Reference

Flies heterozygous for H^P8 show highly penetrant L5 vein shortening phenotype and less penetrant L4 shortening.

(Nagel et al., 2016)

Heterozygotes show loss of macrochaetae.

(Maier et al., 2002)

In H¹/H^P8 flies a complete transformation of all external sensory organ neurons into sheath cells. In H⁹⁹/H^P8 flies causes transformations of external cells to double sockets.

(Nagel et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

H^P8 has visible | dominant phenotype, enhanceable by CycG^HR7/CycG^HR7

(Nagel et al., 2016)

NOT Enhanced by

Statement

Reference

H^P8 has visible phenotype, non-enhanceable by dx²⁴

(Nagel et al., 2000)

NOT suppressed by

Statement

Reference

H^P8 has visible phenotype, non-suppressible by dx²⁴

(Nagel et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

H^P8 has wing vein | adult stage phenotype, enhanceable by CycG^HR7/CycG^HR7

(Nagel et al., 2016)

NOT Enhanced by

Statement

Reference

H^P8 has macrochaeta phenotype, non-enhanceable by dx²⁴

(Nagel et al., 2000)

H^P8 has tormogen cell | ectopic phenotype, non-enhanceable by dx²⁴

(Nagel et al., 2000)

H^P8 has trichogen cell phenotype, non-enhanceable by dx²⁴

(Nagel et al., 2000)

Suppressed by

Statement

Reference

H⁹⁹/H^P8 has trichogen cell phenotype, suppressible by Scer\GAL4^sca-537.4/numb^UAS.cWa

(Nagel et al., 2000)

H⁹⁹/H^P8 has tormogen cell | ectopic phenotype, suppressible by Scer\GAL4^sca-537.4/numb^UAS.cWa

(Nagel et al., 2000)

NOT suppressed by

Statement

Reference

H^P8 has macrochaeta phenotype, non-suppressible by dx²⁴

(Nagel et al., 2000)

H^P8 has tormogen cell | ectopic phenotype, non-suppressible by dx²⁴

(Nagel et al., 2000)

H^P8 has trichogen cell phenotype, non-suppressible by dx²⁴

(Nagel et al., 2000)

Enhancer of

Statement

Reference

H^P8 is an enhancer of mechanosensory sensory organ phenotype of Hsap\APLP2::Hsap\APP^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Merdes et al., 2004)

H^P8 is an enhancer of mechanosensory sensory organ phenotype of Hsap\APP^UAS.Tag:MYC, Scer\GAL4^sca-537.4

(Merdes et al., 2004)

Additional Comments

Genetic Interactions

Statement

Reference

Proportion of flies with both L4 and L5 vein shortening phenotype was significantly increased in H^P8/+ CycG^HR7/CycG^HR7 mutants compared to H^P8/+ alone.

(Nagel et al., 2016)

the addition of numb^Scer\UAS.cWa driven by Scer\GAL4^sca-537.4 to H⁹⁹/H^P8 flies rescues the double socket phenotype seen in the external sensory organs in these flies.

(Nagel et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

H^P8 is rescued by H^Δ1.hs

(Maier et al., 2002)

H^P8 is rescued by H^hs.PM

(Maier et al., 2002)

Partially rescued by

H^P8 is partially rescued by H^Δ3.hs

(Maier et al., 2002)

H^P8 is partially rescued by H^Δ1.2.hs

(Maier et al., 2002)

H^P8 is partially rescued by H^Cfs.hs

(Maier et al., 2002)

H^P8 is partially rescued by H^Δ2.hs

(Maier et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

H^P8

(Frankenreiter et al., 2021, Gomez-Lamarca et al., 2018, Chan et al., 2017, Zehender et al., 2017, Nagel et al., 2016, Praxenthaler et al., 2015, Walrad et al., 2011)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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