FlyBase Allele Report: Dmel\dx[24]

General Information

Symbol

Dmel\dx²⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0045558

Feature type

allele

Associated gene

Dmel\dx

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

loss of function allele

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Fuwa et al., 2006)

loss of function allele

(Matsuno et al., 1995)

Mutagen

Progenitor genotype

Cytology

Description

8bp deletion 175bp downstream of the putative start codon, resulting in the first 59 amino acid residues of dx being fused with a 79 amino acid peptide originating from the out-of-frame sequence presumably generated by the frameshift.

(Fuwa et al., 2006)

Frameshift after the first 59 amino acids of the open reading frame.

(Wilkin et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

X:6,534,590..6,534,597 [+]

Comment:

Frameshift after the first 59 amino acids of the open reading frame.

(Fuwa et al., 2006, Wilkin et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Hing et al., 1999)

visible

(Fuwa et al., 2006, Matsuno et al., 1995)

visible (with dx¹⁵²)

(Fuwa et al., 2006)

visible | recessive

(Hori et al., 2004, Hing et al., 1999)

Phenotype Manifest In

wing

(Hing et al., 1999)

wing (with dx¹⁵²)

(Fuwa et al., 2006)

wing | distal

(Hori et al., 2004)

wing vein

(Fuwa et al., 2006, Matsuno et al., 1995)

wing vein (with dx¹⁵²)

(Fuwa et al., 2006)

Detailed Description

Statement

Reference

Homozygous and dx²⁴/dx¹⁵² flies show wing vein thickening, with the severity of the phenotype being stronger in the dx²⁴/dx¹⁵² flies.

(Fuwa et al., 2006)

Hemizygous males show distal wing blade notching.

(Hori et al., 2004)

Small deltas of extra vein material visible where the veins meet the margin.

(Matsuno et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dx²⁴ has lethal phenotype, enhanceable by M285^M285

(Go and Artavanis-Tsakonas, 1998)

Suppressed by

Statement

Reference

dx²⁴ has visible | dominant phenotype, suppressible by H²/H[+]

(Nagel et al., 2000)

NOT Enhancer of

Statement

Reference

dx²⁴ is a non-enhancer of visible phenotype of H^P8

(Nagel et al., 2000)

Suppressor of

Statement

Reference

dx²⁴ is a suppressor of visible | dominant phenotype of H²

(Nagel et al., 2000)

NOT Suppressor of

Statement

Reference

dx²⁴ is a non-suppressor of visible phenotype of H^P8

(Nagel et al., 2000)

Other

Statement

Reference

Ser^CS94/Ser[+], dx²⁴ has viable phenotype

(Fuwa et al., 2006)

Hsc70-4¹⁹⁵, dx²⁴ has lethal phenotype

(Hing et al., 1999)

Hsc70-4^PG4, dx²⁴ has viable phenotype

(Hing et al., 1999)

Hsc70-4^PG4, dx²⁴ has visible phenotype

(Hing et al., 1999)

Hsc70-4^XK1, dx²⁴ has viable phenotype

(Hing et al., 1999)

Hsc70-4^XK1, dx²⁴ has visible phenotype

(Hing et al., 1999)

Hsc70-4^PA2, dx²⁴ has viable phenotype

(Hing et al., 1999)

Hsc70-4^PA2, dx²⁴ has visible phenotype

(Hing et al., 1999)

Hsc70-4^PB2, dx²⁴ has viable phenotype

(Hing et al., 1999)

Hsc70-4^PB2, dx²⁴ has visible phenotype

(Hing et al., 1999)

Hsc70-4^EJ3, dx²⁴ has viable phenotype

(Hing et al., 1999)

Hsc70-4^EJ3, dx²⁴ has visible phenotype

(Hing et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

dx²⁴ has wing phenotype, enhanceable by Hsc70-4¹⁹⁵

(Hing et al., 1999)

Suppressed by

Statement

Reference

dx²⁴ has wing vein phenotype, suppressible by H²/H[+]

(Nagel et al., 2000)

dx²⁴ has wing phenotype, suppressible by H²/H[+]

(Nagel et al., 2000)

NOT suppressed by

Statement

Reference

dx²⁴ has wing phenotype, non-suppressible by H²/H[+]

(Nagel et al., 2000)

NOT Enhancer of

Statement

Reference

dx²⁴ is a non-enhancer of macrochaeta phenotype of H^P8

(Nagel et al., 2000)

dx²⁴ is a non-enhancer of tormogen cell | ectopic phenotype of H^P8

(Nagel et al., 2000)

dx²⁴ is a non-enhancer of trichogen cell phenotype of H^P8

(Nagel et al., 2000)

Suppressor of

Statement

Reference

dx²⁴ is a suppressor of wing vein phenotype of H²

(Nagel et al., 2000)

NOT Suppressor of

Statement

Reference

dx²⁴ is a non-suppressor of macrochaeta phenotype of H^P8

(Nagel et al., 2000)

dx²⁴ is a non-suppressor of tormogen cell | ectopic phenotype of H^P8

(Nagel et al., 2000)

dx²⁴ is a non-suppressor of trichogen cell phenotype of H^P8

(Nagel et al., 2000)

Other

Statement

Reference

Hsc70-4¹⁹⁵, dx²⁴ has eye phenotype

(Hing et al., 1999)

Hsc70-4^PG4, dx²⁴ has macrochaeta phenotype

(Hing et al., 1999)

Hsc70-4^XK1, dx²⁴ has macrochaeta phenotype

(Hing et al., 1999)

Hsc70-4^PA2, dx²⁴ has macrochaeta phenotype

(Hing et al., 1999)

Hsc70-4^PB2, dx²⁴ has macrochaeta phenotype

(Hing et al., 1999)

Hsc70-4¹⁹⁵, dx²⁴ has leg phenotype

(Hing et al., 1999)

Hsc70-4^EJ3, dx²⁴ has macrochaeta phenotype

(Hing et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Effects on wing development by dx²⁴/Y and H²/+ are mutually levelled. dx²⁴/Y wing phenotypes, both regarding vein broadening and spread out wings, as well as haploinsufficient vein shortening in H² mutants are largely restored in dx²⁴/Y, H²/+ flies. Yet the fragile wing texture typical of dx mutants remains.

(Nagel et al., 2000)

Escaper of the lethality in combination with Hsc70-4¹⁹⁵ show tiny wings, small eyes, malformed legs and die shortly after eclosure.

(Hing et al., 1999)

70% of dx²⁴ flies carrying N^ΔECN.hs show complete rescue.

(Matsuno et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescued by

dx²⁴ is partially rescued by dx^UAS.cMa/Scer\GAL4^hs.PB

(Matsuno et al., 2002)

dx²⁴ is partially rescued by dx^{mRZF.UAS.Tag:GST}/Scer\GAL4^hs.PB

(Matsuno et al., 2002)

Comments

30% individuals carrying dx^hs.PB show complete rescue.

(Matsuno et al., 1995)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

deltex²⁴

(Matsuno et al., 2002)

dx²⁴

(Fuwa et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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