FB2024_03 , released June 25, 2024
Allele: Dmel\Csp1.UAS
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General Information
Symbol
Dmel\Csp1.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0104346
Feature type
allele
Associated gene
Dmel\Csp
Associated Insertion(s)
Carried in Construct
P{UAS-Csp.1}
Key Links
Transgenic product class
cDNA
(Nie et al., 1999)
wild_type
(Nie et al., 1999)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Nie et al., 1999)
wild_type
(Nie et al., 1999)
Mutagen
in vitro construct
(Nie et al., 1999)
Progenitor genotype
Carried in construct
P{UAS-Csp.1}
Cytology
Description

UASt regulatory sequences drive expression of the Csp type 1 cDNA.

(Nie et al., 1999)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Csp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Csp1.Scer\UAS under the control of Scer\GAL4elav-C155 in a wild-type background has no significant effect on evoked excitatory junction potential amplitude at the neuromuscular junction in larvae. Features of spontaneous release are also normal in these larvae. The lethality caused by expression of Csp1.Scer\UAS under the control of Scer\GAL4elav-C155 or Scer\GAL4hs.PB is more severe in male than in female flies. Adult escapers carrying Csp1.Scer\UAS expressed under the control of Scer\GAL4elav-C155 have a short life span, dying within the first 5 days of adulthood at 25oC. The flies are extremely sluggish, show severely uncoordinated movements, and slip frequently. Body size is severely reduced and wing inflation is impaired, so that the wings appear severely crumpled. The regular ommatidial pattern is disrupted so that the eye appears rough. The eye is slightly elliptical in shape and some bristles are lost. Fusion of several ommatidial units is occasionally seen.

      (Nie et al., 1999)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav-C155/Csp1.UAS partially rescues CspR1

      (Nie et al., 1999)
      Comments

      Expression of Csp1.Scer\UAS under the control of Scer\GAL4elav-C155 has no effect on spontaneous miniature excitatory junction potentials at the neuromuscular junction of CspR1 third instar larvae, but does rescue the evoked excitatory junction potential at the neuromuscular junction.

      (Nie et al., 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Csp1.Scer\UAS
      Csp1.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)