FB2024_03 , released June 25, 2024
Allele: Dmel\HemUAS.cHa
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General Information
Symbol
Dmel\HemUAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Hummel
FlyBase ID
FBal0105153
Feature type
allele
Associated gene
Dmel\Hem
Associated Insertion(s)
Carried in Construct
P{UAS-Hem.H}
Also Known As
UAS-Kette
Key Links
Transgenic product class
cDNA
(Hummel et al., 2000)
wild_type
(Hummel et al., 2000)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Hummel et al., 2000)
wild_type
(Hummel et al., 2000)
Mutagen
in vitro construct
(Hummel et al., 2000)
Progenitor genotype
Carried in construct
P{UAS-Hem.H}
Cytology
Description

A full length Hem cDNA is expressed under the control of UASt regulatory sequences.

(Hummel et al., 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hem
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of HemScer\UAS.cHa under the control of Scer\GAL4elav-C155 does not result in any defects in the overall morphology of the embryonic nervous system.

      (Schenck et al., 2004)

      Muscle development in HemScer\UAS.cHa; Scer\GAL4twi.PG embryos appears normal.

      (Schroter et al., 2004)

      Embryos expressing HemScer\UAS.cHa under the control of Scer\GAL4sim.PS in a wild-type background show an abnormal axonal projection phenotype of the VUM neurons.

      (Hummel et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      HemUAS.cHa, Scer\GAL4elav-C155 is a non-suppressor of neuromuscular junction & synapse phenotype of Fmr1EP3517, Scer\GAL4elav-C155

      (Schenck et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The reduced synaptic length seen at the neuromuscular junction in larvae expressing Fmr1EP3517 under the control of Scer\GAL4elav-C155 is not suppressed by co-expression of HemScer\UAS.cHa.

      (Schenck et al., 2004)

      HemScer\UAS.cHa; Scer\GAL4twi.PG partially suppresses the loss of muscle fusion seen in blow2 homozygous embryos. The resulting embryos form fused and attached muscles, although defects in muscle number, size and attachment occur.

      (Schroter et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/HemUAS.cHa rescues HemJ1-70/HemΔ2-6

      (Schenck et al., 2004)
      Partially rescues

      Scer\GAL4twi.PG/HemUAS.cHa partially rescues HemJ4-48

      (Schroter et al., 2004)

      HemUAS.cHa/Scer\GAL4sim.PS partially rescues HemJ4-48

      (Hummel et al., 2000)
      Fails to rescue

      HemUAS.cHa/Scer\GAL4sli.PS fails to rescue Hemunspecified

      (Hummel et al., 2000)
      Comments

      The reduced synaptic length seen at the neuromuscular junction of HemJ1-70/HemΔ2-6 larvae is rescued by expression of HemScer\UAS.cHa under the control of Scer\GAL4elav-C155.

      (Schenck et al., 2004)

      The loss of muscle fusion seen in HemJ4-48 mutant embryos is almost completely rescued by HemScer\UAS.cHa; Scer\GAL4twi.PG.

      (Schroter et al., 2004)

      Fails to rescue the fused commissure phenotype of Hemunspecified embryos when expressed under the control of Scer\GAL4sli.PS. HemScer\UAS.cHa partially rescues the HemJ4-48 phenotype when expressed under the control of Scer\GAL4sim.PS; commissures are separated and connectives are at a further distance from the midline compared to non-rescued HemJ4-48 embryos. The VUM neurons show a normal projection pattern.

      (Hummel et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HemScer\UAS.cHa
      HemUAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hummel
      (Hummel et al., 2000)
      Secondary FlyBase IDs
        References (4)