FlyBase Allele Report: Dmel\trbl[UAS.cGa]

General Information

Symbol

Dmel\trbl^UAS.cGa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Grosshans

FlyBase ID

FBal0117319

Feature type

allele

Associated gene

Dmel\trbl

Associated Insertion(s)

Carried in Construct

P{UAS-trbl.G}

Also Known As

UAS-trbl

Key Links

Transgenic product class

cDNA

(Großhans and Wieschaus, 2000)

wild_type

(Großhans and Wieschaus, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Großhans and Wieschaus, 2000)

wild_type

(Großhans and Wieschaus, 2000)

Mutagen

in vitro construct

(Großhans and Wieschaus, 2000)

Progenitor genotype

Carried in construct

P{UAS-trbl.G}

Cytology

Description

UASt regulatory sequences drive expression of a trbl cDNA.

(Großhans and Wieschaus, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

trbl

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal DNA repair | larval stage, with Scer\GAL4^ci.PU

(Dekanty et al., 2015)

visible, with Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

visible, with Scer\GAL4^GMR.PF

(Price et al., 2002)

visible, with Scer\GAL4^sd-SG29.1

(Price et al., 2002)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PF

(Price et al., 2002)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Price et al., 2002)

wing, with Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

wing disc anterior compartment, with Scer\GAL4^ci.PU

(Dekanty et al., 2015)

wing margin, with Scer\GAL4^sd-SG29.1

(Price et al., 2002)

Detailed Description

Statement

Reference

The expression of trbl^Scer\UAS.cGa under the control of Scer\GAL4^ci.PU leads to a mild increase in DNA damage response (assessed by phospho-H2Av immunostaining) in the wing disc anterior compartment, as compared to controls.

(Dekanty et al., 2015)

Flies expressing trbl^Scer\UAS.cGa under the control of Scer\GAL4^GMR.PF have a slight rough eye phenotype with occasional duplication of bristles. Flies expressing trbl^Scer\UAS.cGa under the control of Scer\GAL4^sd-SG29.1 show scalloping of the wing margin.

(Price et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has visible phenotype, enhanceable by stg^unspecified/stg[+]

(Gawlinski et al., 2007)

Scer\GAL4^sd-SG29.1, trbl^UAS.cGa has visible phenotype, enhanceable by Wee1^UAS.cPa/Scer\GAL4^GMR.PF

(Price et al., 2002)

Scer\GAL4^sd-SG29.1, trbl^UAS.cGa has visible phenotype, enhanceable by Scer\GAL4^sd-SG29.1/Wee1^UAS.cPa

(Price et al., 2002)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has visible phenotype, non-enhanceable by CycE^UAS.cUa, Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has visible phenotype, non-suppressible by CycE^UAS.cUa, Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

Enhancer of

Statement

Reference

Scer\GAL4^sd-SG29.1/trbl^UAS.cGa is an enhancer of visible phenotype of Scer\GAL4^sd-SG29.1, Wee1^UAS.cPa

(Price et al., 2002)

trbl^UAS.cGa/Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Scer\GAL4^sd-SG29.1, Wee1^UAS.cPa

(Price et al., 2002)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has wing phenotype, enhanceable by stg^unspecified/stg[+]

(Gawlinski et al., 2007)

Scer\GAL4^sd-SG29.1, trbl^UAS.cGa has eye phenotype, enhanceable by Wee1^UAS.cPa/Scer\GAL4^GMR.PF

(Price et al., 2002)

Scer\GAL4^sd-SG29.1, trbl^UAS.cGa has interommatidial bristle phenotype, enhanceable by Wee1^UAS.cPa/Scer\GAL4^GMR.PF

(Price et al., 2002)

Scer\GAL4^sd-SG29.1, trbl^UAS.cGa has wing phenotype, enhanceable by Scer\GAL4^sd-SG29.1/Wee1^UAS.cPa

(Price et al., 2002)

NOT Enhanced by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has wing phenotype, non-enhanceable by CycE^UAS.cUa, Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

NOT suppressed by

Statement

Reference

Scer\GAL4^Bx-MS1096, trbl^UAS.cGa has wing phenotype, non-suppressible by CycE^UAS.cUa, Scer\GAL4^Bx-MS1096

(Gawlinski et al., 2007)

Enhancer of

Statement

Reference

Scer\GAL4^sd-SG29.1/trbl^UAS.cGa is an enhancer of wing phenotype of Scer\GAL4^sd-SG29.1, Wee1^UAS.cPa

(Price et al., 2002)

trbl^UAS.cGa/Scer\GAL4^GMR.PF is an enhancer of interommatidial bristle phenotype of Scer\GAL4^sd-SG29.1, Wee1^UAS.cPa

(Price et al., 2002)

trbl^UAS.cGa/Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Scer\GAL4^sd-SG29.1, Wee1^UAS.cPa

(Price et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Coexpression of wee^Scer\UAS.cPa and trbl^Scer\UAS.cGa under the control of Scer\GAL4^sd-SG29.1 results in almost complete ablation of wing tissue. Occasionally, conversion of wing tissue to thoracic tissue is seen.

(Price et al., 2002)

Xenogenetic Interactions

Statement

Reference

The Scer\GAL4^en.PU-driven co-expression of BacA\p35^UAS.cHa and trbl^Scer\UAS.cGa does not significantly affect the DNA damage response kinetics to ionizing ration in the wing disc posterior compartment.

(Dekanty et al., 2015)

Complementation and Rescue Data

Rescues

trbl^UAS.cGa/Scer\GAL4^{VP16.mat.αTub67C} rescues Df(3L)ri-79c

(Großhans and Wieschaus, 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

trbl^Scer\UAS.cGa

trbl^UAS.cGa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Grosshans

(Großhans and Wieschaus, 2000)

Secondary FlyBase IDs

References (7)

Report Sections

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