FlyBase Allele Report: Dmel\rin[1]

General Information

Symbol

Dmel\rin¹

Species

D. melanogaster

Name

FlyBase ID

FBal0117391

Feature type

allele

Associated gene

Dmel\rin

Associated Insertion(s)

P{lacW}rin¹

Carried in Construct

Also Known As

P4957

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pazman et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{lacW}rin¹

Cytology

Description

P{lacW} insertion in an alternative exon in the 5' UTR.

(Pazman et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{lacW}

enhancer trap

Encoded product / tool

lacZ

reporter enzyme

Tagged with

Tag:NLS(P)

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:13,647,383..13,647,546

(Costa et al., 2013, Pazman et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity | recessive

(Pazman et al., 2000)

partially lethal - majority live (with Df(3R)urd)

(Costa et al., 2013)

viable

(Pazman et al., 2000)

viable (with rin²)

(Pazman et al., 2000)

visible (with rin²)

(Pazman et al., 2000)

visible | recessive

(Pazman et al., 2000)

Phenotype Manifest In

eye

(Pazman et al., 2000)

eye (with rin²)

(Pazman et al., 2000)

eye disc

(Pazman et al., 2000)

eye photoreceptor cell

(Pazman et al., 2000)

ommatidium

(Pazman et al., 2000)

ommatidium (with rin²)

(Pazman et al., 2000)

Detailed Description

Statement

Reference

Hemizygous rin[1]/Df(3R)urd flies emerge at a lower than expected frequency compared to their heterozygous siblings.

Homozygous rin¹ flies have normal lifespan.

(Costa et al., 2013)

Homozygotes and rin¹/rin² flies are viable and show a mild rough eye phenotype. Homozygous eyes show defects in both photoreceptor recruitment and ommatidial polarity. Many ommatidia have fewer than the wild-type complement of 8 photoreceptors and some have extra photoreceptors. Both inner and outer photoreceptors can be affected. Many mutant ommatidia with the normal complement of photoreceptors show polarity defects; both the degree and direction of rotation and the chirality of the ommatidia can be affected. The recruitment and polarity defects are evident in third larval instar imaginal discs.

(Pazman et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

rin¹/rin[+] is a suppressor of visible phenotype of Ras85D^V12.sev

(Pazman et al., 2000)

rin¹/rin[+] is a suppressor of visible phenotype of svp^2.sev

(Pazman et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

rin¹/rin[+] is an enhancer of photoreceptor cell R7 phenotype of Sos^JC2, sev⁶

(Pazman et al., 2000)

NOT Enhancer of

Statement

Reference

rin¹ is a non-enhancer of phenotype of RasGAP1^1-16

(Pazman et al., 2000)

rin¹ is a non-enhancer of phenotype of RasGAP1^UAS.cGa, Scer\GAL4^hs.2sev

(Pazman et al., 2000)

Suppressor of

Statement

Reference

rin¹/rin[+] is a suppressor of eye phenotype of svp^2.sev

(Pazman et al., 2000)

rin¹/rin[+] is a suppressor of eye phenotype of Ras85D^V12.sev

(Pazman et al., 2000)

rin¹/rin[+] is a suppressor of phenotype of sev^S11.Tag:MYC

(Pazman et al., 2000)

rin¹/rin[+] is a suppressor of ommatidium phenotype of sev^S11.Tag:MYC

(Pazman et al., 2000)

rin¹/rin[+] is a suppressor of photoreceptor cell R7 | ectopic phenotype of sev^S11.Tag:MYC

(Pazman et al., 2000)

NOT Suppressor of

Statement

Reference

rin¹ is a non-suppressor of phenotype of RasGAP1^1-16

(Pazman et al., 2000)

rin¹ is a non-suppressor of phenotype of RasGAP1^UAS.cGa, Scer\GAL4^hs.2sev

(Pazman et al., 2000)

rin¹ is a non-suppressor of phenotype of Raf::tor^12D.sev

(Pazman et al., 2000)

rin¹ is a non-suppressor of phenotype of rl^Sem

(Pazman et al., 2000)

Additional Comments

Genetic Interactions

Statement

Reference

The extra R7 photoreceptor cells seen in flies carrying sev^{S11.T:Hsap\MYC} are reduced to an average of 2.71 +/- 0.23 R7 photoreceptor cells per ommatidium if the flies are also carrying rin¹. 18.7% of ommatidia have an R7 cell in sev⁶; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹; 13.9% of ommatidia have an R7 cell in sev⁶; Sos^JC2/+ ; rin¹/+ flies.

28.7% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2 flies. This partial rescue of sev⁶ by Sos^JC2 is relieved by rin¹ or rin²; 13.9% and 18.2% of ommatidia have an R7 cell in sev⁶ ; Sos^JC2/+ ; rin¹/+ and sev⁶ ; Sos^JC2/+ ; rin²/+ flies respectively.

(Pazman et al., 2000)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

rin¹/rin² is rescued by rin^Tub.PP

(Pazman et al., 2000)

rin¹ is rescued by rin^Tub.PP

(Pazman et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

9302

w^*; P{lacW}rin¹

Notes on Origin

Discoverer

Selected as: a modifier of the svp^2.sev eye phenotype.

(Pazman et al., 2000)

Comments

The rin¹ homozygous phenotype and the dominant suppression of the svp^2.sev eye phenotype are revertable on excision of the P-element.

(Pazman et al., 2000)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

P4957

(Pazman et al., 2000)

rin¹

(Costa et al., 2013)

rin^P

(Pazman et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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