FlyBase Allele Report: Dmel\Raf::tor[12D.sev]

General Information

Symbol

Dmel\Raf::tor^12D.sev

Species

D. melanogaster

Name

FlyBase ID

FBal0050252

Feature type

allele

Associated gene

Raf::tor

Associated Insertion(s)

Carried in Construct

P{sev-Raf^tor9}

Also Known As

sev-Raf^torY9

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Dickson et al., 1996)

Progenitor genotype

Carried in construct

P{sev-Raf^tor9}

Cytology

Description

Construct: Activated phl::tor construct with same amino acid replacement in tor segment as for tor^12D, whose expression is governed by two copies of the sev enhancer and the sev promoter.

(Dickson et al., 1996)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

Raf::tor

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Morey et al., 2001)

Phenotype Manifest In

eye

(Morey et al., 2001, Lim et al., 1997, Dickson et al., 1996)

ommatidium

(Morey et al., 2001)

photoreceptor cell R7

(Dickson et al., 1996)

photoreceptor cell R7 | ectopic

(Morey et al., 2001)

photoreceptor cell R7 | increased number

(Rintelen et al., 2003)

Detailed Description

Statement

Reference

Flies expressing phl::tor^12D.sev have extra R7 photoreceptors in the eye.

(Rintelen et al., 2003)

phl::tor^12D.sev/+ eyes have a eyes with a highly irregular ommatidial pattern in which more than 70% of ommatidia have multiple R7-like cells.

(Morey et al., 2001)

Flies carrying phl::tor^12D.sev have a rough eye phenotype.

(Lim et al., 1997)

Rough eye phenotype, as for phl::tor^12D.hs.sev.

(Dickson et al., 1996)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Raf::tor^12D.sev has visible | dominant phenotype, suppressible by Sps1^k11320

(Morey et al., 2001)

Phenotype Manifest In

Enhanced by

Statement

Reference

Raf::tor^12D.sev has eye phenotype, enhanceable by Dsor1^Su4

(Lim et al., 1997)

Raf::tor^12D.sev has eye phenotype, enhanceable by spen^14O1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, enhanceable by spen^16H1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, enhanceable by spen^16T1

(Dickson et al., 1996)

Suppressed by

Statement

Reference

Raf::tor^12D.sev has eye phenotype, suppressible by Catⁿ¹

(Morey et al., 2001)

Raf::tor^12D.sev has eye phenotype, suppressible by Sps1^k11320

(Morey et al., 2001)

Raf::tor^12D.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by Catⁿ¹

(Morey et al., 2001)

Raf::tor^12D.sev has photoreceptor cell R7 | ectopic phenotype, suppressible by Sps1^k11320

(Morey et al., 2001)

Raf::tor^12D.sev has photoreceptor cell R7 phenotype, suppressible by Catⁿ¹

(Morey et al., 2001)

Raf::tor^12D.sev has photoreceptor cell R7 phenotype, suppressible by Sps1^k11320

(Morey et al., 2001)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^16Q1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^17G1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^17K2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^22E1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by Su(Raf)3C^17M1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by phyl²

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by phyl³

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^14D1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^14D5

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^15M1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by 14-3-3ε^18A2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^15S2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^17B1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^17C1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^18B1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^18U1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^19E1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^19U1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^20K2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^20M2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^21N1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by Hsp83^13F3

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by rl^21P1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by Hsp83^19F2

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by Hsp83^9J1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^11L1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^14C6

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^15D1

(Dickson et al., 1996)

Raf::tor^12D.sev has eye phenotype, suppressible by lilli^16F1

(Dickson et al., 1996)

NOT suppressed by

Statement

Reference

Raf::tor^12D.sev has phenotype, non-suppressible by rin¹

(Pazman et al., 2000)

Raf::tor^12D.sev has phenotype, non-suppressible by rin²

(Pazman et al., 2000)

Other

Statement

Reference

Raf::tor^12D.sev, lilli^3E8 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, lilli^4U5 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, lilli^5J1 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, phyl¹ has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, rl^8M4 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, rl^2M1 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, rl^4H6 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, rl^2L1 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, lilli^5X5 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, rl^6L1 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Raf::tor^12D.sev, lilli^4P5 has photoreceptor cell R7 phenotype

(Dickson et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The addition of SelD^k11320/+ to phl::tor^12D.sev/+ animals suppresses the eye phenotype so that 60% of ommatidia have the normal set of photoreceptors. Catⁿ¹ also suppresses these phenotypes.

(Morey et al., 2001)

The phl::tor^12D.sev rough eye phenotype is greatly enhanced by Dsor1^Su4.

(Lim et al., 1997)

Eye phenotype enhanced by alleles of spen. Eye phenotype suppressed by alleles of lilli, rl, phyl, Hsp83, 14-3-3ε and Su(Raf)3C.

(Dickson et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

B. Dickson and E. Hafen.

(Dickson et al., 1996)

Comments

Used as a basis for a genetic screen for modifiers of Raf activity.

(Dickson et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Raf::tor^12D.sev

Raf^tor9

(Dickson et al., 1996)

Raf^torY9

(Morey et al., 2001)

Raf^torY

(Morey et al., 2001)

phl::tor^12D.sev

sev-Raf^torY9

(Lim et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (5)

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