FlyBase Allele Report: Dmel\Kr-h1[EP2289]

General Information

Symbol

Dmel\Kr-h1^EP2289

Species

D. melanogaster

Name

FlyBase ID

FBal0119471

Feature type

allele

Associated gene

Dmel\Kr-h1

Associated Insertion(s)

P{EP}Kr-h1^EP2289

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(McGovern et al., 2003, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}Kr-h1^EP2289

Cytology

Description

Inserted 562bp downstream from the start of the hkb first exon.

(McGovern et al., 2003)

The P{EP} element is inserted within the 5' UTR.

(Kraut et al., 2001)

P{EP} insertion at +562bp of the transcription unit.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:6,081,790..6,082,067 [+]

(Riddiford et al., 2018, McGovern et al., 2003, Pena-Rangel et al., 2002, Tseng and Hariharan, 2002, Gene Disruption Project members, 2001-, Kraut et al., 2001, Kraut et al., 2001, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^en-e16E

(Tseng and Hariharan, 2002)

lethal, with Scer\GAL4^sca-4512

(McGovern et al., 2003)

visible, with Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

visible, with Scer\GAL4^hs.2sev

(Tseng and Hariharan, 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

adult abdomen & microchaeta, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

dorsocentral bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

eye, with Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

eye, with Scer\GAL4^hs.2sev

(Tseng and Hariharan, 2002)

larval intersegmental nerve, with Scer\GAL4^elav-C155

(Kraut et al., 2001)

larval ventral nerve cord commissure, with Scer\GAL4^sca-4512

(McGovern et al., 2003)

scutellar bristle, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Detailed Description

Statement

Reference

Ventral nerve cord commissures in stage 17 hh^EP3521; Scer\GAL4^sca-4512 embryos are fused and/or 'fuzzy'.

(McGovern et al., 2003)

Expression of Kr-h1^EP2289 under the control of Scer\GAL4^ey.PH results in eyes that are strongly reduced in size. Flies expressing Kr-h1^EP2289 under the control of Scer\GAL4^hs.2sev have glassy eyes.

(Tseng and Hariharan, 2002)

Mutant larvae expressing Kr-h1^EP2289 under the control of Scer\GAL4^elav-C155 have ISN neuron pathfinding defects.

(Kraut et al., 2001)

Expression of Kr-h1^EP2289 under the control of Scer\GAL4^sca-537.4 results in severe loss of microchaetae on the abdomen and loss of scutellar and dorsocentral macrochaetae, and short and thickened shaft morphology.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Kr-h1^EP2289, Scer\GAL4^ey.PH has visible phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Other

Statement

Reference

Kr-h1^EP2289, Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+] has lethal | pupal stage phenotype

(Pena-Rangel et al., 2002)

Kr-h1^EP2289, Scer\GAL4^pnr-MD237, pnr^MD237 has lethal | pupal stage phenotype

(Pena-Rangel et al., 2002)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Kr-h1^EP2289, Scer\GAL4^ey.PH has eye phenotype, non-suppressible by CycE^UAS.cLa, Scer\GAL4^ey.PH

(Tseng and Hariharan, 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of CycE^Scer\UAS.cLa does not suppress the small eye phenotype caused by expression of Kr-h1^EP2289 under the control of Scer\GAL4^ey.PH.

(Tseng and Hariharan, 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

EP(2)2289

(Abdelilah-Seyfried et al., 2000)

EP2289

(Kang et al., 2017)

Kr-h1^EP2289

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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