FlyBase Allele Report: Dmel\tou[EP622]

General Information

Symbol

Dmel\tou^EP622

Species

D. melanogaster

Name

FlyBase ID

FBal0119662

Feature type

allele

Associated gene

Dmel\tou

Associated Insertion(s)

P{EP}tou^EP622

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{EP}tou^EP622

Cytology

Description

P{EP} insertion.

(Abdelilah-Seyfried et al., 2000)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:11,616,004..11,616,004 [-]

(Vanolst et al., 2005, Zhu et al., 2005, Pena-Rangel et al., 2002, Gene Disruption Project members, 2001-, Abdelilah-Seyfried et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

visible, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

Phenotype Manifest In

dorsocentral bristle, with Scer\GAL4^ap-md544

(Vanolst et al., 2005)

dorsocentral bristle | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

dorsocentral bristle | increased number, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

scutellar bristle | ectopic, with Scer\GAL4^sca-537.4

(Abdelilah-Seyfried et al., 2000)

scutellar bristle | increased number, with Scer\GAL4^ap-md544

(Pena-Rangel et al., 2002)

Detailed Description

Statement

Reference

Flies in which tou^EP622 is overexpressed under the control of Scer\GAL4^ap-md544 exhibit an excess of dorsocentral bristles on the heminotum (an average of 2.78 compared to 2.0 per heminotum)

(Vanolst et al., 2005)

Flies expressing tou^EP622 under the control of Scer\GAL4^ap-md544 have extra dorsocentral and scutellar macrochaetae.

(Pena-Rangel et al., 2002)

Expression of tou^EP622 under the control of Scer\GAL4^sca-537.4 results in additional scutellar and dorsocentral macrochaetae.

(Abdelilah-Seyfried et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^sca-537.4, tou^EP622 has visible phenotype, non-enhanceable by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^sca-537.4, tou^EP622 has visible phenotype, non-suppressible by N[+]/N^55e11

(Abdelilah-Seyfried et al., 2000)

Enhancer of

Statement

Reference

tou^EP622, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Scer\GAL4^pnr-MD237/tou^EP622 is an enhancer of visible phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

tou^EP622, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Scer\GAL4^GMR.PF/tou^EP622 is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/tou^EP622 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

tou^EP622, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

tou^EP622, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Scer\GAL4^GMR.PF/tou^EP622 is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^pnr-MD237/tou^EP622 is an enhancer of adult thorax phenotype of pnr^MD237

(Pena-Rangel et al., 2002)

NOT Enhancer of

Statement

Reference

Scer\GAL4^GMR.PF/tou^EP622 is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Scer\GAL4^sca-537.4/tou^EP622 is a non-enhancer of phenotype of N^55e11

(Abdelilah-Seyfried et al., 2000)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/tou^EP622 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

tou^EP622, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/tou^EP622 is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Other

Statement

Reference

Chi^E, Scer\GAL4^ap-md544, tou^EP622 has dorsocentral bristle phenotype

(Vanolst et al., 2005)

Scer\GAL4^pnr-MD237, pnr^MD237, tou^EP622 has scutellum phenotype

(Pena-Rangel et al., 2002)

Scer\GAL4^pnr-MD237, pnr^MD237/pnr[+], tou^EP622 has scutellum phenotype

(Pena-Rangel et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of tou^EP622, under the control of Scer\GAL4^ap-md544 in Chi^E homozygous flies results in suppression of the dorsocentral bristle loss observed in Chi^E mutants. Double mutants exhibit an average of 2.23 dorsocentral bristles per heminotum compared to 2.0 in wild-type.

(Vanolst et al., 2005)

pnr^MD237/+ adults expressing tou^EP622 under the control of Scer\GAL4^pnr-MD237 have strong thoracic and scutellar clefts.

(Pena-Rangel et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Selected as: a P{EP} insertion line that modifies the pnr^MD237/+ phenotype when expressed using Scer\GAL4^pnr-MD237.

(Pena-Rangel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

EP(2)0622

(Abdelilah-Seyfried et al., 2000)

EP0622^EP0622

EP622^EP622

tou^EP622

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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