FB2024_03 , released June 25, 2024
Allele: Dmel\Rac1V12.C.UAS
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General Information
Symbol
Dmel\Rac1V12.C.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0120652
Feature type
allele
Associated gene
Dmel\Rac1
Associated Insertion(s)
Carried in Construct
P{UAS-Rac1.V12.C}
Key Links
Transgenic product class
missense_variant
(Chang and Ready, 2000)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Chang and Ready, 2000)
Mutagen
in vitro construct
(Chang and Ready, 2000)
Progenitor genotype
Carried in construct
P{UAS-Rac1.V12.C}
Cytology
Description

UASt regulatory sequences drive expression of mutated, constitutively active Rac1 (carries the amino acid replacement G12V).

(Chang and Ready, 2000)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rac1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      Scer\GAL4hs.PB/Rac1V12.C.UAS is a suppressor of rhabdomere & actin filament phenotype of ninaE17

      (Chang and Ready, 2000)

      Scer\GAL4hs.PB/Rac1V12.C.UAS is a suppressor of rhabdomere phenotype of ninaE17

      (Chang and Ready, 2000)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Rac1V12.C.Scer\UAS under the control of Scer\GAL4hs.PB during rhabdomere morphogenesis substantially rescues rhabdomere morphogenesis in ninaE17 mutants. Occasional loops of rhabdomere membrane are seen intruded into the photoreceptor, but most terminate at a well-defined base. The rhabdomere terminal web (RTW) is more tightly organised. Substantial rescue is seen 5 days after eclosion. About 18% of R1-R6 rhabdomeres are rescued in non-heat shocked animals, rising to 90% in animals heat shocked at 80% of pupal development.

      (Chang and Ready, 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Rac1V12.C.Scer\UAS
      Rac1V12.C.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)