FlyBase Allele Report: Dmel\RpL15[PΔ8]

General Information

Symbol

Dmel\RpL15^PΔ8

Species

D. melanogaster

Name

FlyBase ID

FBal0123786

Feature type

allele

Associated gene

Dmel\RpL15

Associated Insertion(s)

P{}RpL15^PΔ8

Carried in Construct

Also Known As

l(3)80Fi^PΔ8

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Schulze et al., 2005)

Mutagen

Delta2-3 transposase

(Schulze et al., 2001)

P-element activity

(Sinclair et al., 2000)

Progenitor genotype

Associated Insertion(s)

P{}RpL15^PΔ8

Cytology

Description

Insertion of a 1780bp P-element in the RpL15 promoter region. The P-element is inserted in the same orientation as the direction of transcription of RpL15.

(Schulze et al., 2005)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | female (with RpL15³)

(Sinclair et al., 2000)

lethal | recessive

(Schulze et al., 2001)

partially lethal (with RpL15³)

(Schulze et al., 2005)

partially lethal (with RpL15^7-1)

(Schulze et al., 2005)

partially lethal (with RpL15^8-1)

(Schulze et al., 2005)

partially lethal (with RpL15^PΔ2)

(Schulze et al., 2005)

sterile (with RpL15³)

(Schulze et al., 2001)

sterile (with RpL15^7-1)

(Schulze et al., 2001)

sterile (with RpL15^8-1)

(Schulze et al., 2001)

sterile (with RpL15⁷²)

(Schulze et al., 2001)

visible (with RpL15³)

(Schulze et al., 2001)

visible (with RpL15^7-1)

(Schulze et al., 2001)

visible (with RpL15^8-1)

(Schulze et al., 2001)

visible (with RpL15⁷²)

(Schulze et al., 2001)

Phenotype Manifest In

eye (with RpL15³)

(Schulze et al., 2001)

eye (with RpL15^7-1)

(Schulze et al., 2001)

eye (with RpL15^8-1)

(Schulze et al., 2001)

eye (with RpL15⁷²)

(Schulze et al., 2001)

gonad (with RpL15³)

(Schulze et al., 2001)

gonad (with RpL15^7-1)

(Schulze et al., 2001)

gonad (with RpL15^8-1)

(Schulze et al., 2001)

gonad (with RpL15⁷²)

(Schulze et al., 2001)

macrochaeta (with RpL15³)

(Schulze et al., 2001)

macrochaeta (with RpL15^7-1)

(Schulze et al., 2001)

macrochaeta (with RpL15^8-1)

(Schulze et al., 2001)

macrochaeta (with RpL15⁷²)

(Schulze et al., 2001)

male genitalia (with RpL15³)

(Schulze et al., 2001)

male genitalia (with RpL15^7-1)

(Schulze et al., 2001)

male genitalia (with RpL15^8-1)

(Schulze et al., 2001)

male genitalia (with RpL15⁷²)

(Schulze et al., 2001)

wing (with RpL15³)

(Schulze et al., 2001)

wing (with RpL15^7-1)

(Schulze et al., 2001)

wing (with RpL15^8-1)

(Schulze et al., 2001)

wing (with RpL15⁷²)

(Schulze et al., 2001)

wing hair (with RpL15³)

(Schulze et al., 2001)

wing hair (with RpL15^7-1)

(Schulze et al., 2001)

wing hair (with RpL15^8-1)

(Schulze et al., 2001)

wing hair (with RpL15⁷²)

(Schulze et al., 2001)

wing vein (with RpL15³)

(Schulze et al., 2001)

wing vein (with RpL15^7-1)

(Schulze et al., 2001)

wing vein (with RpL15^8-1)

(Schulze et al., 2001)

wing vein (with RpL15⁷²)

(Schulze et al., 2001)

Detailed Description

Statement

Reference

Homozygous escapers (which are sterile) are occasionally seen.

(Schulze et al., 2005)

Adult survivors transheterozygotes with RpL15³, RpL15⁷², RpL15^7-1 or RpL15^8-1 are sterile with underdeveloped gonads and show reduced body size, small and thin bristles, rough and/or reduced eyes, misrotated genitalia (males) and wing, wing vein and wing hair phenotypes. Reducing the growth temperature to 22^oC (as compared to 25^oC) increases the incidence of homozygote survivors. Sex ratios are also skewed in favour of females in the survivors. Exceptions are the RpL15^PΔ2/RpL15^PΔ8 and RpL15^7-1/RpL15^PΔ8 combinations where sex ratios are normal.

(Schulze et al., 2001)

Only RpL15³/RpL15^PΔ8 males eclose.

(Sinclair et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially complements

RpL15^7-1

(Schulze et al., 2001)

RpL15^8-1

(Schulze et al., 2001)

RpL15^PΔ2

(Schulze et al., 2001)

Fails to complement

RpL15⁷²

(Schulze et al., 2001)

RpL15³

(Schulze et al., 2001)

Rescued by

RpL15^PΔ2/RpL15^PΔ8 is rescued by Scer\GAL4^Act5C.PU/RpL15^cDNA.UAS

(Schulze et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

PΔ8

(Schulze et al., 2005)

RpL15^PΔ8

l(3)80Fi^PΔ8

(Schulze et al., 2001, Sinclair et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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