FlyBase Allele Report: Dmel\brn[l.6P6]

General Information

Symbol

Dmel\brn^l.6P6

Species

D. melanogaster

Name

FlyBase ID

FBal0125109

Feature type

allele

Associated gene

Dmel\brn

Associated Insertion(s)

Carried in Construct

Also Known As

brn^1.6P6

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

dorsal appendage

(Goode et al., 1996)

embryonic/larval neuromuscular junction (with brn^fs.107)

(Huang et al., 2018)

follicle cell

(Goode et al., 1996)

follicle cell (with brn^fs.107)

(Smith et al., 2002)

lamina plexus

(Fan et al., 2005)

photoreceptor cell R1 & axon

(Fan et al., 2005)

photoreceptor cell R2 & axon

(Fan et al., 2005)

photoreceptor cell R3 & axon

(Fan et al., 2005)

photoreceptor cell R4 & axon

(Fan et al., 2005)

photoreceptor cell R5 & axon

(Fan et al., 2005)

photoreceptor cell R6 & axon

(Fan et al., 2005)

terminal bouton | larval stage (with brn^fs.107)

(Huang et al., 2018)

Detailed Description

Statement

Reference

brn^fs.107/brn^l.6P6 larvae have significantly increased bouton number and satellite bouton number at the neuromuscular junction of muscle 4, compared to controls, with no effect on bouton size.

(Huang et al., 2018)

brn^l.6P6 mutant larval peripheral nerves have a diameter comparable to wild-type nerves, and similarly to wild-type, do not show attached plasmatocytes.

(Dahlgaard et al., 2012)

In brn^l.6P6 third instar visual systems, R-cell axonal projections are defective and the lamina plexus is discontinuous and of variable thickness.

(Fan et al., 2005)

Strong brn allele.

(Goode et al., 1996)

Follicle cells line the wall of the germarium but only sometimes extend processes, leading to split cysts. They frequently lose their cuboidal or columnar shape and exit the epithelium around the oocyte and its adjacent nurse cells. Also follicle cells at the posterior end of the egg chamber become mesenchymal-like indicating they have not adopted a border cell fate.

(Goode et al., 1996)

Homozygous females lay eggs with fused dorsal appendages: embryos show neurogenic phenotypes. Neurogenic phenotype of brn^l.6P6 is more extreme than that of brn^fs.107.

(Goode et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

brn^l.6P6 has lethal | recessive phenotype, suppressible by Cele\bre-5^UAS.cGa/Scer\GAL4^Act5C.PI

(Griffitts et al., 2003)

brn^l.6P6 has lethal | recessive phenotype, suppressible by Cele\bre-5^UAS.cGa/Scer\GAL4^arm.PS

(Griffitts et al., 2003)

brn^l.6P6 has lethal | recessive phenotype, suppressible by Cele\bre-5^UAS.cGa/Scer\GAL4^hs.PB

(Griffitts et al., 2003)

NOT suppressed by

Statement

Reference

brn^l.6P6, egh^9pp4 has abnormal neuroanatomy phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6 has lethal | recessive phenotype, non-suppressible by Scer\GAL4^Act5C.PI/Hsap\B3GNT4^UAS.cMa

(Griffitts et al., 2003)

brn^l.6P6 has lethal | recessive phenotype, non-suppressible by Scer\GAL4^hs.PB/Hsap\B3GNT4^UAS.cMa

(Griffitts et al., 2003)

brn^l.6P6 has lethal | recessive phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\B3GNT4^UAS.cMa

(Griffitts et al., 2003)

brn^l.6P6 has lethal | pupal stage phenotype, non-suppressible by Hsap\B3GNT5^UAS.cMa/Scer\GAL4^arm.PS

(Muller et al., 2002)

brn^l.6P6 has lethal | pupal stage phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\B3GNT4^UAS.cMa

(Muller et al., 2002)

brn^l.6P6 has lethal | pupal stage phenotype, non-suppressible by Scer\GAL4^arm.PS/Hsap\B4GAT1^UAS.cMa

(Muller et al., 2002)

NOT Enhancer of

Statement

Reference

brn^l.6P6 is a non-enhancer of abnormal neuroanatomy phenotype of egh^9pp4

(Fan et al., 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

brn^fs.107/brn^l.6P6 has follicle cell phenotype, enhanceable by da[+]/da²

(Smith et al., 2002)

NOT Enhanced by

Statement

Reference

brn^l.6P6 has photoreceptor cell R2 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

brn^l.6P6 has photoreceptor cell R3 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

brn^l.6P6 has photoreceptor cell R4 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

brn^l.6P6 has photoreceptor cell R5 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

brn^l.6P6 has photoreceptor cell R6 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

brn^l.6P6 has photoreceptor cell R1 & axon phenotype, non-enhanceable by egh^9pp4

(Fan et al., 2005)

NOT suppressed by

Statement

Reference

brn^l.6P6, egh^9pp4 has photoreceptor cell R1 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R2 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R3 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R4 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R5 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

brn^l.6P6, egh^9pp4 has photoreceptor cell R6 & axon phenotype, non-suppressible by Hsap\B4GALT6^UAS.cWa/Scer\GAL4^arm.PS

(Fan et al., 2005)

NOT Enhancer of

Statement

Reference

brn^l.6P6 is a non-enhancer of photoreceptor cell R4 & axon phenotype of egh^9pp4

(Fan et al., 2005)

brn^l.6P6 is a non-enhancer of photoreceptor cell R5 & axon phenotype of egh^9pp4

(Fan et al., 2005)

brn^l.6P6 is a non-enhancer of photoreceptor cell R6 & axon phenotype of egh^9pp4

(Fan et al., 2005)

brn^l.6P6 is a non-enhancer of photoreceptor cell R1 & axon phenotype of egh^9pp4

(Fan et al., 2005)

brn^l.6P6 is a non-enhancer of photoreceptor cell R2 & axon phenotype of egh^9pp4

(Fan et al., 2005)

brn^l.6P6 is a non-enhancer of photoreceptor cell R3 & axon phenotype of egh^9pp4

(Fan et al., 2005)

Other

Statement

Reference

brn^l.6P6, grk³ has dorsal appendage phenotype

(Goode et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

The R-cell axonal projection phenotype of brn^l.6P6 and egh^9pp4 mutants is not enhanced when flies carry both mutations simultaneously.

(Fan et al., 2005)

Eggs derived from brn^l.6P6/brn⁺; grk³/grk⁺ females show an intermediate to strong fused dorsal appendage phenotype that is indistinguishable from eggs laid by brn females.

(Goode et al., 1996)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\β4Gal-T6^Scer\UAS.cWa, under the control of Scer\GAL4^arm.PS, in egh^9pp4 mutants rescues the R-cell axonal projection phenotype. However, Scer\GAL4^arm.PS > Hsap\β4Gal-T6^Scer\UAS.cWa expression does not rescue the R-cell axonal projection phenotype in brn^l.6P6 egh^9pp4 double mutants.

(Fan et al., 2005)

Complementation and Rescue Data

Rescued by

brn^l.6P6 is rescued by brn^UAS.cMa/Scer\GAL4^arm.PS

(Griffitts et al., 2003)

brn^l.6P6 is rescued by Scer\GAL4^Act5C.PI/brn^UAS.cMa

(Griffitts et al., 2003)

brn^l.6P6 is rescued by brn^UAS.cMa/Scer\GAL4^hs.PB

(Griffitts et al., 2003)

brn^l.6P6 is rescued by brn^UAS.cMa/Scer\GAL4^arm.PS

(Muller et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (5)

Bloomington

50762

y¹ w^* brn^l.6P6/FM7a

600473

y¹ egh^9pp4 brn^l.6P6 sn²/FM6, w¹

600468

y¹ w^* brn^l.6P6 f^36a P{neoFRT}18A/FM6, w¹

600472

y¹ egh^9pp4 brn^l.6P6 sn² P{neoFRT}18A/FM7i, P{ActGFP}JMR3

600469

y¹ w^* brn^l.6P6 sn² P{FRT(w^hs)}101/FM6, w¹

Notes on Origin

Discoverer

Comments

Allelic series in the ovary: brn²²⁸ > brn^l.6P6 (germline clones) = brn¹⁹⁸ > brn^fs.107. Zygotic requirement for brn alleles (strongest to weakest): brn^l.6P6 > brn²²⁸ > brn¹⁹⁸ > brn^fs.107.

(Swan et al., 2001)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

6P6

(Perrimon et al., 1989)

Brn^1.6P6

(Wandall et al., 2005)

brn^1.6P6

(Huang et al., 2018, Dahlgaard et al., 2012, Hamel et al., 2010, Chen et al., 2007, Fan et al., 2005, Griffitts et al., 2003, Muller et al., 2002, Smith et al., 2002, Swan et al., 2001, Goode et al., 1996)

brn²

brn^l.6P6

l(1)6P6

(Goode et al., 1992)

Name Synonyms

Secondary FlyBase IDs

FBal0001302
FBal0030649

References (15)

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