FB2024_03 , released June 25, 2024
Allele: Dmel\Sac1BG02228
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General Information
Symbol
Dmel\Sac1BG02228
Species
D. melanogaster
Name
FlyBase ID
FBal0125489
Feature type
allele
Associated gene
Dmel\Sac1
Associated Insertion(s)
P{GT1}Sac1BG02228
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Gene Disruption Project members, 2001-)
Progenitor genotype
Associated Insertion(s)
P{GT1}Sac1BG02228
Cytology
Description

Insertion 30bp downstream of the predicted transcription start site.

(Wei et al., 2003)
Allele components
Component
Use(s)
Inserted element
P{GT1}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN8OSCTG112.UAS
      (Mutsuddi et al., 2004)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos have dorsal anterior holes in the cuticle. The mutant embryos do not show premature apical constriction of amnioserosa cells. Sac1BG02228/Sac1L2F embryos have dorsal anterior holes in the cuticle and puckering of the dorsal cuticle.

      (Wei et al., 2003)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Sac1[+]/Sac1BG02228 is an enhancer of abnormal neuroanatomy phenotype of Hsap\ATXN8OSCTG112.UAS, Scer\GAL4GMR.PF

      (Mutsuddi et al., 2004)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      pucE69 Sac1L2F double heterozygous embryos show defects in the dorsal cuticle (anterior head holes and/or puckering). Sac1BG02228 shows no genetic interactions with pucE69 or bsk1.

      (Wei et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Excision of the P{GT1} element can revert the lethal phenotype.

      (Wei et al., 2003)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      BG02228
      (Mutsuddi et al., 2004)
      CG9128BG02228
      Sac1BG02228
      (Christensen et al., 2008.4.15, Christensen et al., 2007.10.29)
      sac1BG02228
      (Han et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)