FlyBase Allele Report: Dmel\Tak1[1]

General Information

Symbol

Dmel\Tak1¹

Species

D. melanogaster

Name

FlyBase ID

FBal0126475

Feature type

allele

Associated gene

Dmel\Tak1

Associated Insertion(s)

Carried in Construct

Also Known As

dTak1¹, TAK1

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Vidal et al., 2001)

Progenitor genotype

Cytology

Description

The Tak1¹ mutation is within the kinase domain of the expressed product.

(Delaney et al., 2006)

Amino acid replacement: D159G.

(Vidal et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

X:20,522,714..20,522,714 [-]

Nucleotide change:

A20522714G

Amino acid change:

D159G | Tak1-PA

Reported amino acid change:

D159G

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. Authors report in paper that mutation is D158G, however their protein sequence in Figure 5 clearly shows that D159G is the correct mutation.

(Vidal et al., 2001)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.UAS, Tace^RNAi.UAS.cSa

(Chabu and Xu, 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response

(Meinander et al., 2012, Geuking et al., 2009, Leulier et al., 2006, Leulier et al., 2002, Vidal et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant flies show greatly reduced survival compared to wild type after septic injury with Erwinia carotovora carotovora 15.

(Meinander et al., 2012)

The survival rate of Tak1¹ mutant flies following challenge with Erwinia carotovora 15 (Ecc15) is similar to wild type.

(Geuking et al., 2009)

Tak1¹ mutant flies are highly susceptible to infection by gram-negative bacteria, and the majority die within 25 hours of septic injury. Animals are not susceptible to gram-positive bacteria or fungal infection, and survival rates are comparable to wild-type.

(Leulier et al., 2006)

The eyes of Tak1¹ flies have normal morphology.

(Cha et al., 2003)

Mutant animals are highly susceptible to Gram-negative bacterial infection, exhibiting a dramatic loss of survival rate after infection, with all animals dying within 2 days.

(Leulier et al., 2002)

Flies are susceptible to Gram-negative bacterial infection.

(Vidal et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Tak1[+]/Tak1¹ is a suppressor | partially of increased cell death | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Tak1[+]/Tak1¹ is a suppressor | partially of visible | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Tak1[+]/Tak1¹ is a suppressor | partially of decreased size | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Tak1¹ is a suppressor | cell non-autonomous of neoplasia | somatic clone | cell autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, Tak1^UAS.cTa

(Chabu and Xu, 2014)

Tak1¹ is a suppressor of increased cell death phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Ma et al., 2012)

Tak1¹ is a suppressor of partially lethal - majority die phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

Tak1¹ is a suppressor of visible | adult stage phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

Phenotype Manifest In

Suppressor of

Statement

Reference

Tak1[+]/Tak1¹ is a suppressor | partially of wing phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Tak1[+]/Tak1¹ is a suppressor | partially of wing disc | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Tak1¹ is a suppressor | cell non-autonomous of eye disc | somatic clone | cell autonomous | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU, Tak1^UAS.cTa

(Chabu and Xu, 2014)

Tak1¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Ma et al., 2012)

Tak1¹ is a suppressor of wing phenotype of PGRP-LF²⁰⁰

(Maillet et al., 2008)

Tak1¹ is a suppressor of ommatidium phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Tak1¹ is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Tak1¹ is a suppressor of eye photoreceptor cell phenotype of Scer\GAL4^GMR.PF, Traf4^EP578

(Cha et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of Tace^GD572 suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the adjacent cells are homozygous mutant for Tak1¹.

Expression of Tace^{dsRNA.Scer\UAS} suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The phenotype is further suppressed when the adjacent cells are homozygous mutant for Tak1¹.

(Chabu and Xu, 2014)

egr^Scer\UAS.cIa-induced cell death is partially suppressed in hemizygous Tak1¹ mutant males.

(Ma et al., 2012)

Tak1¹ suppresses the notching phenotypes and low adult viability seen in homozygous PGRP-LF²⁰⁰ mutants.

(Maillet et al., 2008)

Scer\GAL4^GMR.PF>Traf1^EP578 expression in a Tak1¹ background block the rough-eye phenotype caused by Traf1^EP578 overexpression.

(Cha et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Tak1¹⁷⁹

(Delaney et al., 2006)

Partially rescued by

Tak1¹ is partially rescued by Tak1^UAS.cTa/Scer\GAL4^hs.PB

(Vidal et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

D10¹

(Vidal et al., 2001)

DTAK1¹

(Cha et al., 2003)

TAK1

(Agaisse et al., 2003)

TAK1¹

(Kim et al., 2006, Zaidman-Remy et al., 2006)

TAK1^D10

(Zhai et al., 2018)

Tak1

(Maillet et al., 2008)

Tak1¹

(Gendrin et al., 2013, Ma et al., 2012, Meinander et al., 2012, Clark et al., 2011, Geuking et al., 2009, Leulier et al., 2006)

dTAK1¹

(Delaney et al., 2006)

dTak1

(Chabu and Xu, 2014)

dTak1¹

(Khush et al., 2002)

dTak¹

(Tavignot et al., 2017)

tak1¹

(Wada et al., 2021, Park et al., 2004)

Name Synonyms

Secondary FlyBase IDs

References (21)

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