FlyBase Allele Report: Dmel\Cdk7[S164A.T170A]

General Information

Symbol

Dmel\Cdk7^S164A.T170A

Species

D. melanogaster

Name

FlyBase ID

FBal0126632

Feature type

allele

Associated gene

Dmel\Cdk7

Associated Insertion(s)

Carried in Construct

P{Cdk7.S164A.T170A}

Also Known As

cdk7^S164A/T170A

Key Links

Transgenic product class

missense_variant

(Larochelle et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

missense_variant

(Larochelle et al., 2001)

Mutagen

in vitro construct

(Larochelle et al., 2001)

Progenitor genotype

Cdk7^+tLa

(Larochelle et al., 2001)

Carried in construct

P{Cdk7.S164A.T170A}

Cytology

Description

Construct: Amino acid replacement: T170A. Amino acid replacement: S164A.

(Larochelle et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

Cdk7

Encoded product / tool

Cdk7

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell death | temperature conditional

(Morishita et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Cdk7^S164A.T170A mutant imaginal discs do not display massive apoptosis when subjected to gamma irradiation, indicating a suppression of apoptosis in these mutants.

(Morishita et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cdk7^S164A.T170A is a suppressor of increased cell death phenotype of Scer\GAL4^vg.PU, hid^UAS.cUa

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of increased cell death phenotype of hid^GMR.PG

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of increased cell death phenotype of rpr^GMR.PW

(Morishita et al., 2013)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cdk7^S164A.T170A is a suppressor of wing phenotype of Scer\GAL4^vg.PU, hid^UAS.cUa

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of eye phenotype of ninaE^G69D.GMR

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of ommatidium phenotype of ninaE^G69D.GMR

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of eye phenotype of hid^GMR.PG

(Morishita et al., 2013)

Cdk7^S164A.T170A is a suppressor of eye phenotype of rpr^GMR.PW

(Morishita et al., 2013)

NOT Suppressor of

Statement

Reference

Cdk7^S164A.T170A is a non-suppressor of eye phenotype of Hsap\CDKN1A^GMR.PH

(Morishita et al., 2013)

Cdk7^S164A.T170A is a non-suppressor of ommatidium phenotype of Hsap\CDKN1A^GMR.PH

(Morishita et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

A Cdk7^S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of p53^Scer\UAS.Ex in the developing eye, under the control of Scer\GAL4^GMR.PF.

A Cdk7^S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of rpr^GMR.PW in the developing eye.

A Cdk7^S164A.T170A mutant background significantly suppresses the partial eye ablation found upon expression of W^GMR.PG in the developing eye.

(Morishita et al., 2013)

Xenogenetic Interactions

Statement

Reference

A Cdk7^S164A.T170A mutant background does not suppress the ommatidial fusion found upon expression of Hsap\CDKN1A^GMR.PH in the developing eye.

(Morishita et al., 2013)

Complementation and Rescue Data

Partially rescues

Cdk7^S164A.T170A partially rescues Df(1)JB254

(Larochelle et al., 2001)

Comments

The addition of Cdk7^S164A.T170A rescues the Cdk7^- phenotype of Df(1)JB254 at 18^oC but not at 25^oC and 29^oC.

(Larochelle et al., 2001)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

98097

y¹ w^*; P{Cdk7.S164A.T170A}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CDK7^S164A,T170A

(Cho et al., 2020)

Cdk7^S164A.T170A

cdk7^S164A/T170A

(Larochelle et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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