FB2024_03 , released June 25, 2024
Allele: Dmel\Tre1ΔEP5
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General Information
Symbol
Dmel\Tre1ΔEP5
Species
D. melanogaster
Name
FlyBase ID
FBal0127254
Feature type
allele
Associated gene
Dmel\Tre1
Associated Insertion(s)
Carried in Construct
Also Known As
tre1epΔ5
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
Delta2-3 transposase
(Ueno et al., 2001)
Progenitor genotype
P{EP}Tre1EP496
(Ueno et al., 2001)
Caused by aberration
Df(1)TreΔEP5
Cytology
Description

Distal breakpoint falls in the first intron of Tre1. Proximal breakpoint lies within the first Gr5a intron, which lies 3' to the codon specifying Arg 36. The translation initiation codon of Gr5a is removed.

(Dahanukar et al., 2001)

Imprecise excision of the progenitor insertion, resulting in a 2.5kb deletion of genomic sequences uncovering 0.9kb towards Gr5a (removing the promoter, 5' leader sequences and sequences to 133bp downstream of the start codon) and 1.6b towards Tre1 (removing the promoter, exon 1 and part of intron 1).

(Ueno et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:5,678,368..5,680,859 [-]
Comment:

2492 bp deletion associated with the imprecise excision of P{EP}Tre1EP496 (GB:AB066611).

(Ueno et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
AB066611
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos derived from mutant mothers are defective in the first active step of germ cell migration, the transepithelial migration through the posterior midgut (PMG). Germ cells in mutant embryos do not transmigrate the PMG, but remain clumped together within midgut pocket. At the end of embryogenesis, mutant embryos have on average one or two germ cells per gonad, compared to the 12-15 seen in wild-type. The overall number of germ cells seems unaffected. This phenotype is fully penetrant. This phenotype does not seem to be due to a defect in germ cell mobility. When mutant mothers are mated with wild-type males a weaker germ-cell migration phenotype is seen than when both parents are mutant. Embryos mutant only in zygotic Tre1 have no germ cell migration phenotype.

      (Kunwar et al., 2003)
      External Data
      Interactions
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      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (5)
      References (11)