FlyBase Allele Report: Dmel\Psa[UAS.cSa]

General Information

Symbol

Dmel\Psa^UAS.cSa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Schulz

FlyBase ID

FBal0130819

Feature type

allele

Associated gene

Dmel\Psa

Associated Insertion(s)

Carried in Construct

P{UAS-Psa.S}

Key Links

Transgenic product class

cDNA

(Schulz et al., 2001)

wild_type

(Schulz et al., 2001)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Schulz et al., 2001)

wild_type

(Schulz et al., 2001)

Mutagen

in vitro construct

(Schulz et al., 2001)

Progenitor genotype

Carried in construct

P{UAS-Psa.S}

Cytology

Description

UASt regulatory sequences drive expression of a full length Psa cDNA.

(Schulz et al., 2001)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Psa

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Menzies et al., 2010)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal, with Scer\GAL4^da.G32

(Schulz et al., 2001)

lethal, with Scer\GAL4^hs.PB

(Schulz et al., 2001)

lethal, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

lethal, with Scer\GAL4^Ubi.PU

(Schulz et al., 2001)

lethal, with Scer\GAL4^{VP16.nanos.UTR}

(Schulz et al., 2001)

visible, with Scer\GAL4^GMR.PF

(Schulz et al., 2001)

visible, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

Phenotype Manifest In

anterior crossvein, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

eye, with Scer\GAL4^GMR.PF

(Schulz et al., 2001)

metatarsus, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

ommatidium, with Scer\GAL4^GMR.PF

(Schulz et al., 2001)

wing, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

wing hair, with Scer\GAL4^ptc-559.1

(Schulz et al., 2001)

Detailed Description

Statement

Reference

Overexpression of Psa^Scer\UAS.cSa during embryonic and larval development using Scer\GAL4^Ubi, Scer\GAL4^da.G32, Scer\GAL4^{nos.UTR.T:Hsim\VP16}, Scer\GAL4^ptc-559.1 or Scer\GAL4^hs.PB results in lethality. Overexpression of Psa^Scer\UAS.cSa in adult flies using Scer\GAL4^Ubi or Scer\GAL4^hs.PB has no detectable effect. Expression of Psa^Scer\UAS.cSa using Scer\GAL4^GMR.PF results in abnormal eyes. Most ommatidia lack the setal bristle and contain highly melanised cells. Expression of Psa^Scer\UAS.cSa using Scer\GAL4^ptc-559.1 during the pupal stage results in leg and wing defects. The metatarsus is often missing from the legs. The wings lack hair and show signs of melanisation along the antero-posterior border. Interruptions in the radial-medial crossvein connecting veins 3 and 4 are often seen.

(Schulz et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Psa^UAS.cSa, Scer\GAL4^elav-C155 is a suppressor of short lived phenotype of Hsap\HTT^Q93.ex1.UAS, Scer\GAL4^elav-C155

(Menzies et al., 2010)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Psa^Scer\UAS.cSa increases the lifespan of flies expressing Scer\GAL4^elav-C155>Hsap\HTT^{Q93.ex1p.Scer\UAS}.

(Menzies et al., 2010)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Psa^Scer\UAS.cSa

Psa^UAS.cSa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Schulz

(Schulz et al., 2001)

Secondary FlyBase IDs

References (2)

Report Sections

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