FB2024_03 , released June 25, 2024
Allele: Dmel\CG3776EP835
Open Close
General Information
Symbol
Dmel\CG3776EP835
Species
D. melanogaster
Name
FlyBase ID
FBal0131499
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
EP835
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description
Allele components
Component
Use(s)
Mutations Mapped to the Genome
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of CG3776EP835 under the control of Scer\GAL4hs.PB using heat shock during the first or second larval instar results in lethality, while heat shock during the third larval instar results in eclosion of small adults.

Expression of CG3776EP835 under the control of Scer\GAL4hs.PB using heat shock in males does not affect the number of adult progeny from these flies. These males show a high frequency of mating behaviour and also show male-male courtship behaviour.

Expression of CG3776EP835 under the control of Scer\GAL4hs.PB using heat shock in newly eclosed female flies results in a reduced number of adult progeny flies even when the females are mated with normal males. Newly eclosed females expressing CG3776EP835 under the control of Scer\GAL4hs.PB lay significantly fewer eggs than control females (this effect is seen both when they are mated to wild-type males and when they are mated to males expressing CG3776EP835 under the control of Scer\GAL4hs.PB). These females have significantly fewer eggs in their ovaries 4 days after eclosion compared to control females (egg production in these females can be recovered by application of methoprene).

Fecundity is not affected if females carrying CG3776EP835 under the control of Scer\GAL4hs.PB are heat shocked 7 days after eclosion.

CG3776EP835 females (in the absence of a Scer\GAL4 driver) lay significantly more eggs than control females (this effect is seen both when they are mated to wild-type males and when they are mated to CG3776EP835 males).

CG3776EP835 males (in the absence of a Scer\GAL4 driver) show a 38.8% reduction in lifespan compared to controls, while males expressing CG3776EP835 under the control of Scer\GAL4hs.PB show a 42.6% reduction in lifespan compared to controls.

CG3776EP835 females (in the absence of a Scer\GAL4 driver) show a 31.6% reduction in lifespan compared to controls, while females expressing CG3776EP835 under the control of Scer\GAL4hs.PB show a 35% reduction in lifespan compared to controls.

Flies expressing CG3776EP835 under the control of Scer\GAL4hs.PB show increased locomotor activity compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Selected as: a P{EP} insertion line that modifies the pnrMD237/+ phenotype when expressed using Scer\GAL4pnr-MD237.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
CG3776EP835
Jhebp29EP835
l(2)k03704EP835
Name Synonyms
Secondary FlyBase IDs
    References (4)