FlyBase Allele Report: Dmel\Tao[EP1455]

(Pflanz et al., 2015, Gomez et al., 2012, Kapfhamer et al., 2012, King et al., 2011, Poon et al., 2011, King et al., 2007, Zhu et al., 2005, Shulman and Feany, 2003, Gene Disruption Project members, 2001-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman and Feany, 2003)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal chemosensory behavior | adult stage (with Tao⁵⁰)

(King et al., 2011)

abnormal chemosensory behavior | adult stage | recessive

(King et al., 2011)

abnormal neuroanatomy | adult stage

(King et al., 2011)

abnormal size (with Tao⁵⁰)

(Poon et al., 2011)

lethal, with Scer\GAL4^Tub.PU

(Gomez et al., 2012)

visible | adult stage (with Tao⁵⁰)

(Poon et al., 2011)

Phenotype Manifest In

adult mushroom body alpha-lobe

(King et al., 2011)

adult mushroom body beta-lobe

(King et al., 2011)

adult mushroom body gamma-lobe

(King et al., 2011)

ellipsoid body | adult stage

(King et al., 2011)

wing (with Tao⁵⁰)

(Poon et al., 2011)

Detailed Description

Statement

Reference

Homozygous male Tao^EP1455 flies exposed to a moderate (non-sedating) concentration of ethanol exhibit reduced hyperactivity compared to wild type. This reduction in hyperactivity is present over a range of ethanol doses and is not observed in heterozygotes. The presence of the phenotype is dependent on the temperature during metamorphosis; flies at 25[o]C during pupariation exhibit reduced hyperactivity whereas locomotor activity in flies that metamorphose at 18[o]C is comparable to wild type. Tao^EP1455 flies are not insensitive to ethanol, as naive flies startle normally on exposure, reaching speeds that are usually observed in the later phases of the hyperactivity response. The rate of ethanol accumulation is also similar to controls. Tao^EP1455 flies are capable of normal locomotion, having an average walking speed that is comparable to wild type. As well as ethanol, Tao^EP1455 mutant flies are also resistant to the effects of other drugs of abuse, exhibiting improved climbing behaviour in response to both cocaine and nicotine in comparison with control flies.

Tao^EP1455/Tao⁵⁰ males exhibit greatly diminished ethanol-induced hyperactivity compared to wild type.

The brains of Tao^EP1455 mutant flies appear normal in size and gross morphology. However, striking differences are seen in the mushroom and ellipsoid bodies. The normally circular ellipsoid body appears open and flattened and the α and β lobes of the mushroom body are absent in most flies. The γ lobes are present but are often thinner than in wild type flies. No defects are observed in other components of the central complex, including the fan-shaped body and the cerebral bridge. However, a FasII-positive ball-like structure is present in the posterior of the brain, adjacent to the mushroom body calices.

(King et al., 2011)

The wings of Tao⁵⁰/Tao^EP1455 mutant flies are 8% larger than controls.

(Poon et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Tao^EP1455 has abnormal neuroanatomy | adult stage phenotype, suppressible by par-1^W3/par-1[+]

(King et al., 2011)

Tao^EP1455 has abnormal neuroanatomy | adult stage phenotype, suppressible by par-1^k05603/par-1[+]

(King et al., 2011)

Tao^EP1455 has abnormal chemosensory behavior | adult stage phenotype, suppressible by par-1^k05603/par-1[+]

(King et al., 2011)

Enhancer of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Cdc42^L89.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Tao^EP1455, Scer\GAL4^GMR.PF is an enhancer of visible phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Tao^EP1455, Scer\GAL4^GMR.PF is a non-enhancer of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Tao^EP1455 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Scer\GAL4^GMR.PF/Tao^EP1455 is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Tao^EP1455, Scer\GAL4^GMR.PF is a suppressor of visible phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Rac1^N17.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

Tao^EP1455, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Phenotype Manifest In

Suppressed by

Statement

Reference

Tao^EP1455 has adult mushroom body beta-lobe phenotype, suppressible by par-1^W3/par-1[+]

(King et al., 2011)

Tao^EP1455 has adult mushroom body gamma-lobe phenotype, suppressible by par-1^W3/par-1[+]

(King et al., 2011)

Tao^EP1455 has adult mushroom body alpha-lobe phenotype, suppressible by par-1^k05603/par-1[+]

(King et al., 2011)

Tao^EP1455 has adult mushroom body beta-lobe phenotype, suppressible by par-1^k05603/par-1[+]

(King et al., 2011)

Tao^EP1455 has adult mushroom body gamma-lobe phenotype, suppressible by par-1^k05603/par-1[+]

(King et al., 2011)

Tao^EP1455 has adult mushroom body alpha-lobe phenotype, suppressible by par-1^W3/par-1[+]

(King et al., 2011)

Enhancer of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is an enhancer of eye phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Tao^EP1455, Scer\GAL4^GMR.PF is an enhancer of ommatidium phenotype of Hsap\MAPT^V337M.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

NOT Enhancer of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is a non-enhancer of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Suppressor of

Statement

Reference

Scer\GAL4^GMR.PF/Tao^EP1455 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl^λ.UAS, stumps^UAS.Tag:FLAG

(Zhu et al., 2005)

Scer\GAL4^GMR.PF/Tao^EP1455 is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, btl::Egfr^λ.UAS

(Zhu et al., 2005)

Tao^EP1455, Scer\GAL4^GMR.PF is a suppressor of eye phenotype of Pvr^λ.UAS, Scer\GAL4^GMR.PF

(Zhu et al., 2005)

NOT Suppressor of

Statement

Reference

Tao^EP1455, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of Hsap\ATXN1^82.UAS, Scer\GAL4^GMR.PF

(Shulman and Feany, 2003)

Additional Comments

Genetic Interactions

Statement

Reference

One copy of par-1^W3 partially suppresses the adult mushroom body morphology defects seen in Tao^EP1455. Approximately half of all brain hemispheres have fully formed mushroom body lobes.

One copy of par-1^k05603 partially suppresses the adult mushroom body morphology defects seen in Tao^EP1455. Approximately half of all brain hemispheres have fully formed mushroom body lobes.

One copy of par-1^k05603 suppresses the reduction in ethanol-induced hyperactivity seen in Tao^EP1455 hemizygotes.

(King et al., 2011)

Xenogenetic Interactions

Statement

Reference

The rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF is enhanced by Tao-1^EP1455.

(Shulman and Feany, 2003)

Complementation and Rescue Data

Rescued by

Tao^EP1455 is rescued by Scer\GAL4^elav-C155, Tao^EP1455

(King et al., 2011)

Tao^EP1455 is rescued by Tao^+tNX19

(King et al., 2011)

Rescues

Scer\GAL4^elav-C155, Tao^EP1455 rescues Tao^EP1455

(King et al., 2011)

Scer\GAL4^GMR.PF/Tao^EP1455 rescues Tao^KK108458

(Poon et al., 2011)

Comments

Expression of Tao^+tNX19 rescues the defects in ethanol induced hyperactivity seen in Tao^EP1455, with flies exhibiting normal or slightly elevated hyperactivity.

Expressing Tao^EP1455 in neurons under the control of Scer\GAL4^elav-C155 rescues the defects in ethanol-induced hyperactivity seen in Tao^EP1455 mutants.

(King et al., 2011)

Expression of Tao^EP1455 rescues the eye overgrowth phenotype seen when Tao^KK108458 is expressed under the control of Scer\GAL4^GMR.PF.

(Poon et al., 2011)

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

11458

w¹¹¹⁸ P{EP}EP1455

600142

w¹¹¹⁸ P{EP}EP1455 Tao^eta P{neoFRT}19A/FM6

Notes on Origin

Discoverer

Comments

Precise excision of the P{EP} element reverts the modifying effect of Tao-1^EP1455 on the rough eye phenotype caused by expression of Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^GMR.PF.

(Shulman and Feany, 2003)

The ethanol induced hyperactivity seen in Tao^EP1455 is restored in lines with precise excision of the P-element.

(King et al., 2011)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG14217^EP1455

(Shulman and Feany, 2003)

EP(X)1455

(King et al., 2011)

EP1455

(King et al., 2011)

Tao-1^EP1455

(Poon et al., 2011)

Tao^EP1455

(King et al., 2011)

tao^EP1455

(Kapfhamer et al., 2012)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

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